Pizza RestaurantRestaurant Delivery ServiceTake Out RestaurantFast Food RestaurantDomino's Pizza
Looking for great pizza in Columbia? At Domino’s, we’re passionate about bringing you the best pizza experience, whether you're carrying out or ordering pizza delivery. Whether you’re craving thin, foldable New York Style pizza or a thick, Handmade Pan pizza, Domino’s has you covered. Or try our delicious, cheesy Parmesan Stuffed Crust pizza today! We offer more than just mouthwatering pizza—dishes like our fan-favorite mac and cheese, salads, pasta, and chicken wings will satisfy all your needs. We’ll give you great value with our unbeatable deals, making it easy to enjoy more for less. Wherever you are, the Domino's Pizza near you is here to satisfy your cravings with taste and quality. Order from 621 Saint Andrews Rd .
Explore offerings from Domino's Pizza on 621 Saint Andrews Rd in Columbia, with popular mix and match, pizza, breads, and chicken available at this location.
Test Menu data- all locations
97 items
Mix and Match
2-Topping Domino
$6.99
Our premium, buttery flavored pan dough encrusted with real Parmesan cheese, and baked in a rectangular pan to create a crispy Parmesan Detroit Style crust. Topped with two layers of cheese and your favorite sauce and up to 3 toppings then finished with our signature garlic seasoning.
2-Topping Medium Pizza
$6.99
A custom pizza made to order. Choose from any of our delicious crust styles, excluding Handmade Pan or Paremsan Crust.
Parmesan Bread Bites
$6.99
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan.
Stuffed Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Pepperoni Stuffed Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed with cheese and pepperoni - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Spinach & Feta Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed with cheese, fresh spinach and Feta cheese - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Bacon & Jalapeño Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed with cheese, smoked bacon and jalapeno peppers - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an addional charge.
Boneless Chicken
$6.99
Breaded chicken made with 100% whole white breast meat. Choose one or more dipping cups for an additional charge.
Hot Buffalo Loaded Chicken
$6.99
Tender bites of breaded chicken made with 100% whole breast white meat topped with hot buffalo sauce, ranch, a blend of cheese made with mozzarella and cheddar, and feta.
Sweet BBQ Bacon Loaded Chicken
$6.99
Tender bites of breaded chicken made with 100% whole breast white meat topped with sweet and smoky honey BBQ sauce, a blend of cheese made with mozzarella and cheddar, and crispy bacon.
Crispy Bacon & Tomato Loaded Chicken
$6.99
Tender bites of breaded chicken made with 100% whole breast white meat topped with garlic Parmesan sauce, a blend of cheese made with mozzarella and cheddar, crispy bacon and tomato.
Spicy Jalapeno-Pineapple Loaded Chicken
$6.99
Tender bites of lightly breaded, 100% whole breast white meat chicken, topped with sweet and spicy mango-habanero sauce, a blend of cheese made with mozzarella and cheddar, jalapeno and pineapple.
5-Cheese Mac & Cheese
$6.99
Our take on the classic. Penne pasta and a blend of cheddar, American, Parmesan-Asiago, mozzarella blend and Alfredo sauce, oven baked to creamy, bubbly perfection.
Spicy Buffalo 5-Cheese Mac & Cheese
$6.99
Our creamy, oven baked 5-cheese Mac & Cheese drizzled with buffalo sauce for a spicy kick.
Chicken Alfredo
$6.99
Grilled chicken breast and creamy Alfredo sauce mixed with penne pasta and baked to perfection.
Philly Cheese Steak
$6.99
Tender slices of steak, American and provolone cheeses, fresh onions, fresh green peppers and fresh mushrooms.
Chicken Bacon Ranch
$6.99
Grilled chicken breast topped with smoked bacon, creamy ranch and provolone cheese.
Italian
$6.99
Pepperoni and ham topped with banana peppers, fresh green peppers, fresh onions and provolone cheese.
Chicken Parm
$6.99
Grilled chicken breast, tomato-basil marinara, Parmesan- Asiago and provolone cheeses.
Buffalo Chicken
$6.99
Grilled chicken breast, ranch, fresh onions, hot buffalo sauce, provolone, cheddar and cheese made with 100% real mozzarella.
Classic Garden
$6.99
A crisp and colorful combination of grape tomatoes, red onions, carrots, red cabbage, cheddar cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Chicken Caesar
$6.99
The makings of a classic: roasted white meat chicken, Parmesan cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Cinnamon Bread Bites
$6.99
Handmade from fresh buttery tasting pan dough, drizzled with cinnamon and sugar. Oven baked to perfection. Served with a side of sweet icing for dipping or drizzling.
Domino's Marbled Cookie Brownie
$6.99
An irresistibly warn and gooey blend of milk chocolate chunk cookie and fudge brownie. This sharable dessert is oven baked at the time of order and cut into 9 pieces.
Chocolate Lava Crunch Cakes
$6.99
Oven-baked chocolate cakes, crunchy on the outside with molten chocolate fudge on the inside.
S’mores Lava Cakes
$6.99
Three decadent oven-baked graham cracker cakes oozing with a chocolatey chip and gooey marshmallow flavored filling. Perfectly topped with a dash of powdered sugar.
Spicy Chicken Bacon Ranch
$9.99
Grilled chicken breast, creamy ranch, smoked bacon, jalapeños, provolone, and cheese made with 100% real mozzarella and finished off with a drizzle of buffalo sauce.
The People's Pizza - Deluxe
$9.99
Savory pepperoni and Italian sausage, fresh green peppers, fresh mushrooms, fresh onions, provolone and cheese made with 100% real mozzarella
ExtravaganZZa
$9.99
Pepperoni, ham, Italian sausage, beef, fresh onions, fresh green peppers, fresh mushrooms and black olives, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
MeatZZa
$9.99
Pepperoni, ham, Italian sausage and beef, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
Honolulu Hawaiian
$9.99
Sliced ham, smoked bacon, pineapple, fresh green peppers, provolone and cheese made with 100% real mozzarella.
Philly Cheese Steak
$9.99
Tender slices of steak, fresh onions, fresh green peppers, fresh mushrooms, provolone and American cheese.
Pacific Veggie
$9.99
Fresh baby spinach, fresh onions, fresh mushrooms, tomatoes, black olives, feta, provolone, cheese made with 100% real mozzarella and sprinkled with a garlic herb seasoning.
Ultimate Pepperoni
$9.99
Two layers of pepperoni sandwiched between provolone, Parmesan-Asiago and cheese made with 100% real mozzarella then sprinkled with oregano.
Memphis BBQ Chicken
$9.99
Grilled chicken breast, honey BBQ sauce, fresh onions, cheddar, provolone and cheese made with 100% real mozzarella
Wisconsin 6-Cheese
$9.99
Feta, provolone, cheddar, Parmesan-Asiago, cheese made with 100% real mozzarella and sprinkled with oregano.
Spinach & Feta
$9.99
Creamy Alfredo sauce, fresh spinach, fresh onions, feta, Parmesan-Asiago, provolone and cheese made with 100% real mozzarella.
Pizza
BYO Domino
Our premium, buttery flavored pan dough encrusted with real Parmesan cheese, and baked in a rectangular pan to create a crispy Parmesan Detroit Style crust. Topped with two layers of cheese and your favorite sauce and up to 3 toppings then finished with our signature garlic seasoning.
Spicy Chicken Bacon Ranch
Grilled chicken breast, creamy ranch, smoked bacon, jalapeños, provolone, and cheese made with 100% real mozzarella and finished off with a drizzle of buffalo sauce.
ExtravaganZZa ™
Pepperoni, ham, Italian sausage, beef, fresh onions, fresh green peppers, fresh mushrooms and black olives, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
MeatZZa™
Pepperoni, ham, Italian sausage and beef, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
Philly Cheese Steak
Tender slices of steak, fresh onions, fresh green peppers, fresh mushrooms, provolone and American cheese.
Honolulu Hawaiian
Sliced Ham, smoked bacon, pineapple, fresh green peppers, provolone and cheese made with 100% real mozzarella.
Pacific Veggie
Fresh spinach, fresh onions, fresh mushrooms, fresh onions, provolone and cheese made with 100% real mozzarella.
The People’s Pizza – Deluxe
Savory pepperoni and Italian sausage, fresh green peppers, fresh mushrooms, fresh onions, provolone and cheese made with 100% real mozzarella.
We’ve combined our customers’ most ordered toppings into the perfect deluxe pizza.
Ultimate Pepperoni
Two layers of pepperoni sandwiched between provolone, Parmesan-Asiago and cheese made with 100% real mozzarella, then sprinkled with oregano.
Memphis BBQ Chicken
Grilled chicken breast, fresh onions, provolone, American cheese, cheddar, cheese made with 100% real mozzarella.
Wisconsin 6-Cheese
Feta, provolone, cheddar, Parmesan-Asiago, cheese made with 100% real mozzarella, then sprinkled with oregano.
Spinach & Feta
Creamy Alfredo sauce, fresh spinach, fresh onions, feta, Parmesan-Asiago, provolone and cheese made with 100% real mozzarella.
Build Your Own
A custom pizza made to order. Choose from any of our delicious crust styles, including Handmade Pan or Parmesan Stuffed Crust.
Breads
Parmesan Bread Bites
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan.
Cinnamon Bread Bites
Handmade from fresh buttery tasting pan dough, drizzled with cinnamon and sugar. Oven baked to perfection. Served with a side of sweet icing for dipping or drizzling.
Stuffed Cheesy Bread
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Pepperoni Stuffed Cheesy Bread
Our oven-baked breadsticks are stuffed with cheese and pepperoni - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Spinach & Feta Cheesy Bread
Our oven-baked breadsticks are stuffed with cheese, fresh spinach and Feta cheese - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Bacon & Jalapeño Cheesy Bread
Our oven-baked breadsticks are stuffed with cheese, smoked bacon and jalapeno peppers - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Chicken
Boneless Chicken
Breaded chicken made with 100% whole white breast meat. Choose one or more dipping cups for an additional charge.
Bone-in Wings
Marinated and oven-baked. Customize with your choice of dipping cup.
Hot Buffalo Bone-in Wings
Marinated and oven-baked, then smothered in hot buffalo sauce. Customize with your choice of dipping cup.
Honey BBQ Bone-in Wings
Marinated and oven-baked, then smothered in honey BBQ sauce. Customize with your choice of dipping cup.
Garlic Parmesan Bone-in Wings
Marinated and oven-baked, then smothered in garlic Parmesan sauce. Customize with your choice of dipping cup.
Sweet Mango Habanero Bone-in Wings
Marinated and oven-baked, then smothered in sweet mango habanero sauce. Customize with your choice of dipping cup.
Hot Buffalo Loaded Chicken
Tender bites of breaded chicken made with 100% whole breast white meat topped with hot buffalo sauce, ranch, a blend of cheese made with mozzarella and cheddar, and feta.
Sweet BBQ Bacon Loaded Chicken
Tender bites of breaded chicken made with 100% whole breast white meat topped with sweet and smoky honey BBQ sauce, a blend of cheese made with mozzarella and cheddar, and crispy bacon.
Crispy Bacon & Tomato Loaded Chicken
Tender bites of breaded chicken made with 100% whole breast white meat topped with garlic Parmesan sauce, a blend of cheese made with mozzarella and cheddar, crispy bacon and tomato.
Spicy Jalapeno-Pineapple Loaded Chicken
Tender bites of lightly breaded, 100% whole breast white meat chicken, topped with sweet and spicy mango-habanero sauce, a blend of cheese made with mozzarella and cheddar, jalapeno and pineapple.
Pastas
5-Cheese Mac & Cheese
Our take on the classic. Penne pasta and a blend of cheddar, American, Parmesan-Asiago, mozzarella blend and Alfredo sauce, oven baked to creamy, bubbly perfection.
Spicy Buffalo 5-Cheese Mac & Cheese
Our creamy, oven baked 5-cheese Mac & Cheese drizzled with buffalo sauce for a spicy kick.
Chicken Alfredo
Grilled chicken breast and creamy Alfredo sauce mixed with penne pasta and baked to perfection.
Oven-Baked Sandwiches
Philly Cheese Steak
Tender slices of steak, American and provolone cheeses, fresh onions, fresh green peppers and fresh mushrooms.
Chicken Bacon Ranch
Grilled chicken breast topped with smoked bacon, creamy ranch and provolone cheese.
Italian
Pepperoni and ham topped with banana peppers, fresh green peppers, fresh onions and provolone cheese.
Chicken Parm
Grilled chicken breast, tomato-basil marinara, Parmesan- Asiago and provolone cheeses.
Buffalo Chicken
Grilled chicken breast, ranch, fresh onions, hot buffalo sauce, provolone, cheddar and cheese made with 100% real mozzarella.
Salads
Classic Garden
A crisp and colorful combination of grape tomatoes, red onions, carrots, red cabbage, cheddar cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Chicken Caesar
The makings of a classic: roasted white meat chicken, Parmesan cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Ranch
A flavorful creamy dressing with touches of buttermilk and garlic.
Balsamic
A light dressing with a blend of balsamic vinegar, oil and garlic.
Caesar
A savory dressing with a combination of garlic, anchovy and subtle notes of cheese.
Desserts
Chocolate Lava Crunch Cakes
Oven-baked chocolate cakes, crunchy on the outside with molten chocolate fudge on the inside.
Domino's Marbled Cookie Brownie
An irresistibly warn and gooey blend of milk chocolate chunk cookie and fudge brownie. This sharable dessert is oven baked at the time of order and cut into 9 pieces.
Cinnamon Bread Bites
Handmade from fresh buttery tasting pan dough, drizzled with cinnamon and sugar. Oven baked to perfection. Served with a side of sweet icing for dipping or drizzling.
S’mores Lava Cakes
Three decadent oven-baked graham cracker cakes oozing with a chocolatey chip and gooey marshmallow flavored filling. Perfectly topped with a dash of powdered sugar.
Drinks
Coca Cola®
Available in 20 oz and 2-liter bottles
Diet Coke®
Available in 20 oz and 2-liter bottles
Sprite®
Available in 20 oz and 2-liter bottles
Fanta® Orange
Available in 20 oz and 2-liter bottles
Dasani® Water
Available in 20 oz bottles
Dip Cups
Slice Sauce Dipping Cup
Creamy and zesty with a hint of Parmesan.
Ranch
A creamy buttermilk ranch dressing with hints of garlic and onion.
Blue Cheese
A creamy dressing with bits of aged blue cheese.
Hot Buffalo
Domino's own spicy buffalo sauce.
Honey BBQ
A sweet and smoky BBQ sauce with bold flavor.
Marinara
A sweet tomato sauce blended with garlic, basil and oregano.
Garlic
A buttery garlic sauce.
Sweet Mango Habanero
A perfect blend of sweet and spicy in one sauce.
Sweet Icing
A thick sweet icing with a hint of vanilla.
Reviews
3.3
535 reviews
5 stars
233
4 stars
63
3 stars
31
2 stars
30
1 star
178
JW
Jada White
Aug 20, 2026
3.0
Thin crust overly cooked. It was toasted. Drive thru attendant needs to do better. I had to hunk my horn to get their attention. Maybe not be a returning customer.
DP
Donald Parker
Aug 16, 2026
5.0
Unique is the absolute best!
WG
Woody Gregory
Aug 11, 2026
2.0
Worst Domino’s pizza ever! Didn’t order a difficult assortment of toppings. Wasn’t sliced. The sausage was piled on just two slices. Cheese was runny and a liquid was also covering the top.
JS
John Small
Aug 10, 2026
5.0
Pizza at this location is always great & right every time.
DM
Damean Mathews
Jul 15, 2026
2.0
We ordered delivery to a location less than 2 miles away (347 Zimalcrest) and it took nearly an hour and a half to get our (relatively simple) order. Watching on the app tracker, which I know is not a 100% accurate thing by any means, we saw the food become ready fairly quickly. It was the fact one driver left the restaurant and just never got to us. 25 minutes later the app said another driver left with our food, which culminated in another 20-30 minute wait for a location less than 2 miles away. No explanation was given for this strange turn of events, either.
When our food got to us it was a good temperature and tasted good, if not 100% accurate (one stuffed crust pizza did not have the asked for crust flavor, and the stuffed bread was barely stuffed with anything). Not a meal or day ruiner, but an off night for a national favorite.
What types of pizzas does Domino's Pizza in Columbia offer?
Domino's offers Specialty Pizzas, as well as custom pizzas on New York Style, Handmade Pan, or Parmesan Stuffed Crust bases.
What are the operating hours for Domino's Pizza in Columbia?
Domino's is open daily from 10:30 AM to midnight, with extended hours until 1:00 AM on Fridays and Saturdays.
Does Domino's Pizza in Columbia offer delivery and pickup options?
Yes, they provide delivery, curbside pickup, and no-contact delivery services.
Where is Domino's Pizza located in Columbia?
The Domino's location is at 621 Saint Andrews Rd, Columbia, SC 29210.
What are the payment methods accepted at Domino's Pizza in Columbia?
They accept various payment options including credit cards, Apple Pay, Google Pay, PayPal, Bitcoin, cash, and more.
Can I order Domino's Pizza online for delivery or pickup?
Yes, orders can be placed online for delivery or carryout through Domino's official website.
Is Domino's Pizza in Columbia suitable for vegetarians?
Yes, Domino's serves vegetarian dishes among its menu offerings.
What nearby places can I visit before or after getting pizza at Domino's Columbia?
Nearby you can visit Liberty Tax Service for tax help, Seven Oaks Animal Hospital for pet care, or POPS Mart #610 convenience store for quick shopping.
How can nearby facilities like SAFE Federal Credit Union or Wash N Go Laundromat add convenience to my visit to Domino's Pizza?
You can handle banking needs at SAFE Federal Credit Union and drop off laundry at Wash N Go Laundromat conveniently near Domino's, making errands efficient.
Are there other dining options near Domino's Pizza at Saint Andrews Rd in Columbia?
Yes, nearby dining options include McDonald's for fast food and World Famous Cobbler for classic American cuisine.
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