Pizza RestaurantRestaurant Delivery ServiceTake Out RestaurantFast Food RestaurantDomino's Pizza
Looking for great pizza in Clemson? At Domino’s, we’re passionate about bringing you the best pizza experience, whether you're carrying out or ordering pizza delivery. Whether you’re craving thin, foldable New York Style pizza or a thick, Handmade Pan pizza, Domino’s has you covered. Or try our delicious, cheesy Parmesan Stuffed Crust pizza today! We offer more than just mouthwatering pizza—dishes like our fan-favorite mac and cheese, salads, pasta, and chicken wings will satisfy all your needs. We’ll give you great value with our unbeatable deals, making it easy to enjoy more for less. Wherever you are, the Domino's Pizza near you is here to satisfy your cravings with taste and quality. Order from 501 Old Greenville Highway Ste 4.
Explore offerings from Domino's Pizza on 501 Old Greenville Highway in Clemson, with popular mix and match, pizza, breads, and chicken available at this location.
Test Menu data- all locations
97 items
Mix and Match
2-Topping Domino
$6.99
Our premium, buttery flavored pan dough encrusted with real Parmesan cheese, and baked in a rectangular pan to create a crispy Parmesan Detroit Style crust. Topped with two layers of cheese and your favorite sauce and up to 3 toppings then finished with our signature garlic seasoning.
2-Topping Medium Pizza
$6.99
A custom pizza made to order. Choose from any of our delicious crust styles, excluding Handmade Pan or Paremsan Crust.
Parmesan Bread Bites
$6.99
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan.
Stuffed Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Pepperoni Stuffed Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed with cheese and pepperoni - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Spinach & Feta Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed with cheese, fresh spinach and Feta cheese - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Bacon & Jalapeño Cheesy Bread
$6.99
Our oven-baked breadsticks are stuffed with cheese, smoked bacon and jalapeno peppers - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an addional charge.
Boneless Chicken
$6.99
Breaded chicken made with 100% whole white breast meat. Choose one or more dipping cups for an additional charge.
Hot Buffalo Loaded Chicken
$6.99
Tender bites of breaded chicken made with 100% whole breast white meat topped with hot buffalo sauce, ranch, a blend of cheese made with mozzarella and cheddar, and feta.
Sweet BBQ Bacon Loaded Chicken
$6.99
Tender bites of breaded chicken made with 100% whole breast white meat topped with sweet and smoky honey BBQ sauce, a blend of cheese made with mozzarella and cheddar, and crispy bacon.
Crispy Bacon & Tomato Loaded Chicken
$6.99
Tender bites of breaded chicken made with 100% whole breast white meat topped with garlic Parmesan sauce, a blend of cheese made with mozzarella and cheddar, crispy bacon and tomato.
Spicy Jalapeno-Pineapple Loaded Chicken
$6.99
Tender bites of lightly breaded, 100% whole breast white meat chicken, topped with sweet and spicy mango-habanero sauce, a blend of cheese made with mozzarella and cheddar, jalapeno and pineapple.
5-Cheese Mac & Cheese
$6.99
Our take on the classic. Penne pasta and a blend of cheddar, American, Parmesan-Asiago, mozzarella blend and Alfredo sauce, oven baked to creamy, bubbly perfection.
Spicy Buffalo 5-Cheese Mac & Cheese
$6.99
Our creamy, oven baked 5-cheese Mac & Cheese drizzled with buffalo sauce for a spicy kick.
Chicken Alfredo
$6.99
Grilled chicken breast and creamy Alfredo sauce mixed with penne pasta and baked to perfection.
Philly Cheese Steak
$6.99
Tender slices of steak, American and provolone cheeses, fresh onions, fresh green peppers and fresh mushrooms.
Chicken Bacon Ranch
$6.99
Grilled chicken breast topped with smoked bacon, creamy ranch and provolone cheese.
Italian
$6.99
Pepperoni and ham topped with banana peppers, fresh green peppers, fresh onions and provolone cheese.
Chicken Parm
$6.99
Grilled chicken breast, tomato-basil marinara, Parmesan- Asiago and provolone cheeses.
Buffalo Chicken
$6.99
Grilled chicken breast, ranch, fresh onions, hot buffalo sauce, provolone, cheddar and cheese made with 100% real mozzarella.
Classic Garden
$6.99
A crisp and colorful combination of grape tomatoes, red onions, carrots, red cabbage, cheddar cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Chicken Caesar
$6.99
The makings of a classic: roasted white meat chicken, Parmesan cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Cinnamon Bread Bites
$6.99
Handmade from fresh buttery tasting pan dough, drizzled with cinnamon and sugar. Oven baked to perfection. Served with a side of sweet icing for dipping or drizzling.
Domino's Marbled Cookie Brownie
$6.99
An irresistibly warn and gooey blend of milk chocolate chunk cookie and fudge brownie. This sharable dessert is oven baked at the time of order and cut into 9 pieces.
Chocolate Lava Crunch Cakes
$6.99
Oven-baked chocolate cakes, crunchy on the outside with molten chocolate fudge on the inside.
S’mores Lava Cakes
$6.99
Three decadent oven-baked graham cracker cakes oozing with a chocolatey chip and gooey marshmallow flavored filling. Perfectly topped with a dash of powdered sugar.
Spicy Chicken Bacon Ranch
$9.99
Grilled chicken breast, creamy ranch, smoked bacon, jalapeños, provolone, and cheese made with 100% real mozzarella and finished off with a drizzle of buffalo sauce.
The People's Pizza - Deluxe
$9.99
Savory pepperoni and Italian sausage, fresh green peppers, fresh mushrooms, fresh onions, provolone and cheese made with 100% real mozzarella
ExtravaganZZa
$9.99
Pepperoni, ham, Italian sausage, beef, fresh onions, fresh green peppers, fresh mushrooms and black olives, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
MeatZZa
$9.99
Pepperoni, ham, Italian sausage and beef, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
Honolulu Hawaiian
$9.99
Sliced ham, smoked bacon, pineapple, fresh green peppers, provolone and cheese made with 100% real mozzarella.
Philly Cheese Steak
$9.99
Tender slices of steak, fresh onions, fresh green peppers, fresh mushrooms, provolone and American cheese.
Pacific Veggie
$9.99
Fresh baby spinach, fresh onions, fresh mushrooms, tomatoes, black olives, feta, provolone, cheese made with 100% real mozzarella and sprinkled with a garlic herb seasoning.
Ultimate Pepperoni
$9.99
Two layers of pepperoni sandwiched between provolone, Parmesan-Asiago and cheese made with 100% real mozzarella then sprinkled with oregano.
Memphis BBQ Chicken
$9.99
Grilled chicken breast, honey BBQ sauce, fresh onions, cheddar, provolone and cheese made with 100% real mozzarella
Wisconsin 6-Cheese
$9.99
Feta, provolone, cheddar, Parmesan-Asiago, cheese made with 100% real mozzarella and sprinkled with oregano.
Spinach & Feta
$9.99
Creamy Alfredo sauce, fresh spinach, fresh onions, feta, Parmesan-Asiago, provolone and cheese made with 100% real mozzarella.
Pizza
BYO Domino
Our premium, buttery flavored pan dough encrusted with real Parmesan cheese, and baked in a rectangular pan to create a crispy Parmesan Detroit Style crust. Topped with two layers of cheese and your favorite sauce and up to 3 toppings then finished with our signature garlic seasoning.
Spicy Chicken Bacon Ranch
Grilled chicken breast, creamy ranch, smoked bacon, jalapeños, provolone, and cheese made with 100% real mozzarella and finished off with a drizzle of buffalo sauce.
ExtravaganZZa ™
Pepperoni, ham, Italian sausage, beef, fresh onions, fresh green peppers, fresh mushrooms and black olives, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
MeatZZa™
Pepperoni, ham, Italian sausage and beef, all sandwiched between two layers of provolone and cheese made with 100% real mozzarella.
Philly Cheese Steak
Tender slices of steak, fresh onions, fresh green peppers, fresh mushrooms, provolone and American cheese.
Honolulu Hawaiian
Sliced Ham, smoked bacon, pineapple, fresh green peppers, provolone and cheese made with 100% real mozzarella.
Pacific Veggie
Fresh spinach, fresh onions, fresh mushrooms, fresh onions, provolone and cheese made with 100% real mozzarella.
The People’s Pizza – Deluxe
Savory pepperoni and Italian sausage, fresh green peppers, fresh mushrooms, fresh onions, provolone and cheese made with 100% real mozzarella.
We’ve combined our customers’ most ordered toppings into the perfect deluxe pizza.
Ultimate Pepperoni
Two layers of pepperoni sandwiched between provolone, Parmesan-Asiago and cheese made with 100% real mozzarella, then sprinkled with oregano.
Memphis BBQ Chicken
Grilled chicken breast, fresh onions, provolone, American cheese, cheddar, cheese made with 100% real mozzarella.
Wisconsin 6-Cheese
Feta, provolone, cheddar, Parmesan-Asiago, cheese made with 100% real mozzarella, then sprinkled with oregano.
Spinach & Feta
Creamy Alfredo sauce, fresh spinach, fresh onions, feta, Parmesan-Asiago, provolone and cheese made with 100% real mozzarella.
Build Your Own
A custom pizza made to order. Choose from any of our delicious crust styles, including Handmade Pan or Parmesan Stuffed Crust.
Breads
Parmesan Bread Bites
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan.
Cinnamon Bread Bites
Handmade from fresh buttery tasting pan dough, drizzled with cinnamon and sugar. Oven baked to perfection. Served with a side of sweet icing for dipping or drizzling.
Stuffed Cheesy Bread
Our oven-baked breadsticks are stuffed and covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Pepperoni Stuffed Cheesy Bread
Our oven-baked breadsticks are stuffed with cheese and pepperoni - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Spinach & Feta Cheesy Bread
Our oven-baked breadsticks are stuffed with cheese, fresh spinach and Feta cheese - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Bacon & Jalapeño Cheesy Bread
Our oven-baked breadsticks are stuffed with cheese, smoked bacon and jalapeno peppers - covered in a blend of cheese made with 100% real mozzarella and cheddar. Seasoned with a touch of garlic and Parmesan. Add marinara or your favorite dipping cup for an additional charge.
Chicken
Boneless Chicken
Breaded chicken made with 100% whole white breast meat. Choose one or more dipping cups for an additional charge.
Bone-in Wings
Marinated and oven-baked. Customize with your choice of dipping cup.
Hot Buffalo Bone-in Wings
Marinated and oven-baked, then smothered in hot buffalo sauce. Customize with your choice of dipping cup.
Honey BBQ Bone-in Wings
Marinated and oven-baked, then smothered in honey BBQ sauce. Customize with your choice of dipping cup.
Garlic Parmesan Bone-in Wings
Marinated and oven-baked, then smothered in garlic Parmesan sauce. Customize with your choice of dipping cup.
Sweet Mango Habanero Bone-in Wings
Marinated and oven-baked, then smothered in sweet mango habanero sauce. Customize with your choice of dipping cup.
Hot Buffalo Loaded Chicken
Tender bites of breaded chicken made with 100% whole breast white meat topped with hot buffalo sauce, ranch, a blend of cheese made with mozzarella and cheddar, and feta.
Sweet BBQ Bacon Loaded Chicken
Tender bites of breaded chicken made with 100% whole breast white meat topped with sweet and smoky honey BBQ sauce, a blend of cheese made with mozzarella and cheddar, and crispy bacon.
Crispy Bacon & Tomato Loaded Chicken
Tender bites of breaded chicken made with 100% whole breast white meat topped with garlic Parmesan sauce, a blend of cheese made with mozzarella and cheddar, crispy bacon and tomato.
Spicy Jalapeno-Pineapple Loaded Chicken
Tender bites of lightly breaded, 100% whole breast white meat chicken, topped with sweet and spicy mango-habanero sauce, a blend of cheese made with mozzarella and cheddar, jalapeno and pineapple.
Pastas
5-Cheese Mac & Cheese
Our take on the classic. Penne pasta and a blend of cheddar, American, Parmesan-Asiago, mozzarella blend and Alfredo sauce, oven baked to creamy, bubbly perfection.
Spicy Buffalo 5-Cheese Mac & Cheese
Our creamy, oven baked 5-cheese Mac & Cheese drizzled with buffalo sauce for a spicy kick.
Chicken Alfredo
Grilled chicken breast and creamy Alfredo sauce mixed with penne pasta and baked to perfection.
Oven-Baked Sandwiches
Philly Cheese Steak
Tender slices of steak, American and provolone cheeses, fresh onions, fresh green peppers and fresh mushrooms.
Chicken Bacon Ranch
Grilled chicken breast topped with smoked bacon, creamy ranch and provolone cheese.
Italian
Pepperoni and ham topped with banana peppers, fresh green peppers, fresh onions and provolone cheese.
Chicken Parm
Grilled chicken breast, tomato-basil marinara, Parmesan- Asiago and provolone cheeses.
Buffalo Chicken
Grilled chicken breast, ranch, fresh onions, hot buffalo sauce, provolone, cheddar and cheese made with 100% real mozzarella.
Salads
Classic Garden
A crisp and colorful combination of grape tomatoes, red onions, carrots, red cabbage, cheddar cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Chicken Caesar
The makings of a classic: roasted white meat chicken, Parmesan cheese and brioche garlic croutons, all atop a blend of romaine and iceberg lettuce.
Ranch
A flavorful creamy dressing with touches of buttermilk and garlic.
Balsamic
A light dressing with a blend of balsamic vinegar, oil and garlic.
Caesar
A savory dressing with a combination of garlic, anchovy and subtle notes of cheese.
Desserts
Chocolate Lava Crunch Cakes
Oven-baked chocolate cakes, crunchy on the outside with molten chocolate fudge on the inside.
Domino's Marbled Cookie Brownie
An irresistibly warn and gooey blend of milk chocolate chunk cookie and fudge brownie. This sharable dessert is oven baked at the time of order and cut into 9 pieces.
Cinnamon Bread Bites
Handmade from fresh buttery tasting pan dough, drizzled with cinnamon and sugar. Oven baked to perfection. Served with a side of sweet icing for dipping or drizzling.
S’mores Lava Cakes
Three decadent oven-baked graham cracker cakes oozing with a chocolatey chip and gooey marshmallow flavored filling. Perfectly topped with a dash of powdered sugar.
Drinks
Coca Cola®
Available in 20 oz and 2-liter bottles
Diet Coke®
Available in 20 oz and 2-liter bottles
Sprite®
Available in 20 oz and 2-liter bottles
Fanta® Orange
Available in 20 oz and 2-liter bottles
Dasani® Water
Available in 20 oz bottles
Dip Cups
Slice Sauce Dipping Cup
Creamy and zesty with a hint of Parmesan.
Ranch
A creamy buttermilk ranch dressing with hints of garlic and onion.
Blue Cheese
A creamy dressing with bits of aged blue cheese.
Hot Buffalo
Domino's own spicy buffalo sauce.
Honey BBQ
A sweet and smoky BBQ sauce with bold flavor.
Marinara
A sweet tomato sauce blended with garlic, basil and oregano.
Garlic
A buttery garlic sauce.
Sweet Mango Habanero
A perfect blend of sweet and spicy in one sauce.
Sweet Icing
A thick sweet icing with a hint of vanilla.
Reviews
3.5
325 reviews
5 stars
155
4 stars
38
3 stars
26
2 stars
16
1 star
90
YS
Yaya Selah
Aug 22, 2026
5.0
I ordered from here the weekend that the students came back for college, and there was ONE lady working in there by herself!! Yet, she greeted me as soon as she saw me, my food was ready, and prepared to my liking. Unfortunately I did not notice her name but kudos to her for doing her job so well and alone on a weekend when college students started school and the town was swamped. Thank you ma'am for your service and shame on Domino's for having her in there alone during such a busy weekend.
DL
David Langley
Aug 14, 2026
2.0
We have ordered pizza from this location 1 time before and had no problems and that is the only reason I'm not giving this place 1 ⭐. We ordered 2 of the specials, we tipped, and we were told that it'd be around an hour. At about 35 minutes in, an employee asked me my name, went and checked to see if our food was ready, and brought us our order. The bites were on top and were hot. We even ate those on the way home. However, once home we found our pizzas were cold and seemed like they had sat for a bit. Mine had 5 topping of which I had gaps in my pizza with little to no toppings and both were supposed to be extra cheese... Prior to ordering from this location, I had not ordered Domino's pizza in years. After this experience, I will never eat at another Domino's again.
SC
Sigmundrik Campbell
Aug 12, 2026
1.0
One star is entirely to high no star wasn’t an option.::: restaurant owners wondering why there sales are poor because you have below par managers running your business for example store 5620 Clemson sc Asst.manager Leann is running the shift today 08/12/2026 2:30 pm .. by the way she’s conducting business completely unaware on how to operate as an manger either she’s burnt out or just don’t care anymore either way people like this is an cancer to business as an whole when sale starts declining Leanna an manger’s just like her is the reason….
SL
Stephanie LaGuardia
Aug 12, 2026
5.0
Order 25 pizzas for an event and they were delicious. The order process online was simple and quick. The pizzas were ready on time. The staff was very friendly and and even offered assistance taking the pizzas to my car. I will definitely be ordering again!
AW
Aden Whittenbeck
Jul 31, 2026
2.0
Pizza was so thin i thought i accidentally ordered stuffed crust, staff was friendly but they need to be trained better
What types of pizzas can I order at Domino's Pizza in Clemson?
You can order a variety of Specialty Pizzas or build your own on New York Style, Handmade Pan, or Parmesan Stuffed Crust at Domino's Pizza in Clemson.
What are the operating hours for delivery and takeout at Domino's Pizza in Clemson?
Domino's Pizza in Clemson operates from 10:30 AM to 1:00 AM Sunday through Wednesday and on Sunday, and until 2:00 AM from Thursday to Saturday for both delivery and takeout.
Does Domino's Pizza in Clemson offer contactless delivery and curbside pickup?
Yes, Domino's Pizza in Clemson offers curbside pickup, delivery, and no-contact delivery services.
What payment methods are accepted at Domino's Pizza in Clemson?
Domino's Pizza in Clemson accepts various payment options including Afterpay, American Express, Android Pay, Apple Pay, Bitcoin, Cash, Check, Contactless Payment, Diners Club, Discover, Financing, Invoice, Klarna, Mastercard, PayPal, Samsung Pay, Traveler's Check, Visa, and Zelle.
Where is Domino's Pizza located in Clemson?
Domino's Pizza is located at 501 Old Greenville Highway, Ste 4, Clemson, SC 29631, USA.
Is Domino's Pizza in Clemson suitable for vegetarians?
Yes, Domino's Pizza in Clemson serves vegetarian dishes.
Can I order Domino's Pizza in Clemson online or through an app?
Yes, you can order online through their website or use their Android and iOS apps available on Google Play and the App Store.
What nearby places can I visit before or after getting pizza at Domino's Pizza in Clemson?
Nearby places include Clemson Nails for a beauty salon experience, Goober's pub for drinks, and China Express for Asian cuisine options, making great spots to visit before or after your pizza meal.
Where can I find car rental services near Domino's Pizza in Clemson?
Car Rentals R Us is located nearby, offering convenient car rental services for customers visiting Domino's Pizza in Clemson.
Are there any banking services near Domino's Pizza in Clemson?
Yes, SouthState Bank and Park Sterling Bank are nearby, providing convenient banking and financial services for customers of Domino's Pizza in Clemson.
Brand Certified Facts from Domino's Pizza
This information is certified by Domino's Pizza and published from the brand's official system of record. Data is distributed through an enterprise-grade knowledge management platform. Learn more about our data sources
Certified August 30, 2026Yext Knowledge Graph
Address
Categories
Geo coordinates
Legal business name
Hours of operation
Phone number
Official website
Syndication Network
Approved business data is pushed to 100+ publishers, including: