Brand Certified
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
4.6(686 reviews)
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
Business Details
4250 Midamerica Lane, St. Louis, MO
63129, United States
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
(314) 894-0700
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
https://www.ihg.com/holidayinnexpress/hotels/us/en/mehlville/stlml/hoteldetail
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
About
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
HotelWedding VenueBusiness Meeting LocationsHoliday Inn Express
Welcome to the new Holiday Inn Express & Suites St. Louis South I-55!
South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55.
Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association.
Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, St. Louis Zoo, Forest Park, River City Casino and much more!
Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly.
Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!
Location
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
4250 Midamerica Lane, St. Louis, MO
63129, United States
Hours
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • May 17, 2026
MondayOpen 24 hours
TuesdayOpen 24 hours
WednesdayOpen 24 hours
ThursdayOpen 24 hours
FridayOpen 24 hours
SaturdayOpen 24 hours
SundayOpen 24 hours
Reviews
4.6
686 reviews
5 stars
509
4 stars
126
3 stars
31
2 stars7
1 star
13
- NHNoah Hakl4 days ago4.0Room was clean, decent size, king bed. Small fridge, decent tv. Outdoor pool but didn't try it, looked pretty solid. Breakfast was donut or pastry and coffee / basic tea. Service was efficient and very friendly. Check in and out went smooth. Didn't try the restaurant on site. Room door was very sticky and made a lot of noise when opened. Bathroom was decent minus the tub/ shower. Shower floor was very pitched, which made standing in it difficult. Didn't feel very stable moving around on it. Water was good, warm and decent pressure. Toilet rocked when standing up off it too. Overall good place to sleep for price.
- ANAshley Nelson4 days ago3.0The hotel has comfortable rooms and friendly staff, which made for a pleasant stay. However, I found the breakfast options a bit limited and the Wi-Fi was spotty at times. Overall, it's a decent place to rest your head for a night or two.
- KBKimberly Brown5 days ago5.0Absolutely loved my stay here! The staff was super friendly and went above and beyond to make me feel welcome. The rooms were clean and comfy, and the breakfast was delicious—definitely a great value for the price!
- ARApril ReneeMay 3, 20264.0The site said an on-site restaurant which it does not have... The location was meh. I was there on business and did not have my own car. There is nothing within walking distance besides a Popeyes. Be prepared to order delivery or pay for a ride share. The rooms are nice and the breakfast was hot and good. If having things to do nearby then you might want to reconsider.
- MSmarcie slaytonMay 1, 20265.0Absolutely great stay! Beds were very comfortable and our room 323 was well equipped. From our local girls at the front desk to Vanessa in the dining room everyone was excellent. Housekeeping were all smiles and accommodating. The front desk staff were knowledgeable about St. LOUIS and gave excellent recommendations for local eats . Thank you local staff ladies. We will see you again.
Frequently Asked Questions About Holiday Inn Express & Suites St. Louis South - I-55 by IHG
What time is check-in and check-out at Holiday Inn Express & Suites St. Louis South - I-55?
Check-in time is 3:00 PM and check-out time is 11:00 AM.
Is breakfast included during the stay?
Yes, a complimentary Express Start breakfast with buffet options is available for free.
Does the hotel provide free Wi-Fi access?
Yes, free Wi-Fi is available in public areas of the hotel.
Is the Holiday Inn Express & Suites St. Louis South - I-55 accessible for guests with mobility needs?
Yes, the hotel offers accessible parking and is mobility accessible with elevator access.
Are pets allowed at the hotel?
No, pets including cats and dogs are not allowed at this property.
What kind of fitness facilities does the hotel provide?
The hotel offers a free fitness center equipped with elliptical machines, treadmills, and free weights.
Are there any meeting or business facilities available?
Yes, the hotel features two meeting rooms and a business center for guest use.
Is there on-site baggage storage and housekeeping services?
Yes, baggage storage is available and housekeeping services are provided daily.
What nearby medical facilities are close to the hotel?
Nearby medical facilities include Mercy Family Physicians, Mercy Clinic OB/Gyn - Butler Hill, Mercy Clinic Primary Care - Butler Hill, and Barnes-Jewish Heart and Vascular Center.
What dining options are available near the hotel for a quick meal?
Nearby dining options include Taco Bell, Pizza Hut Express, Popeyes® Louisiana Kitchen, and Burger King for fast-food and casual meals.
Where can guests fuel their vehicles or find convenience stores near Holiday Inn Express & Suites St. Louis South - I-55?
Guests can find gas stations and convenience stores such as Phillips 66 Gas, Petro Mart, Rocket, and another Phillips 66 nearby for fuel and supplies.
Brand Certified Facts from Holiday Inn Express & Suites St. Louis South - I-55 by IHG
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