We are at the intersection of Highway I-85 & Cole Mill Rd, two miles from Duke University and Duke Medical Center. North Carolina Central University is six miles from our front door and downtown Durham attractions such as Durham Performing Arts Center, Durham Bulls Athletic Park, restaurants, and bars is only four miles away. Breakfast, WiFi, and our five-mile radius shuttle service are included in your stay, as well as access to our fitness center and indoor heated pool.
Location
Hampton Inn & Suites Durham University Medical Center
Guests consistently praised the hotel for its cleanliness, noting that both the rooms and common areas were spotless.
Staff Service
The staff received high marks for their friendliness and helpfulness, with specific mentions of individuals like Priscilla and Wayne who went above and beyond to assist guests.
Breakfast Quality
The breakfast offerings were frequently highlighted as exceptional, with a wide variety of options that catered to different dietary needs.
Location
The hotel is conveniently located near Duke University and medical facilities, making it a preferred choice for visitors to the area.
Amenities
Guests appreciated the range of amenities, including a fitness center, pool, and outdoor seating areas, enhancing their overall experience.
KA
Kendall A.E.
Jan 2, 2026
5.0
Maybe the best "affordable" hotel I've ever been at. The staff was very friendly and helpful, the breakfast was excellent, the lounge and outdoor area was very nice. I loved the board games and fire pit and hot cocoa. Comfy and clean rooms.
KS
Kristina Scott
Jan 1, 2026
5.0
Had a great stay at the Hampton! Breakfast was great. The room was clean & it was huge & wide open.
They had a free shuttle service that we utilized. Our driver Gwen was so kind & friendly. She stoped at the coffee shop for us before dropping us at the train station. She had snacks as well which was nice.
MD
Marc Dreyfuss
Dec 27, 2025
5.0
Deserves more than 5 stars. Very clean. Everything in excellent shape. Good sized rooms. Comfortable beds. Fast elevators. Event the continental breakfast was excellent. Many gluten free and dairy free options (including gluten free toast and oat milk).
SS
Sarah
Dec 24, 2025
5.0
We had to stay overnight in Durham for doctor's visits at Duke University hospital. My last appointment wrapped up early. Check in is at 3pm, we arrived around 2pm, the clerk was able to accommodate early check in! Every staff member was helpful, and pleasant. They were even having free fresh baked cookies that afternoon. The little extra touches were very nice, but what really struck me was how clean and quiet it was.
The lobby was bright, decorated, and very clean. This followed throughout the rest of the hotel. The weight room, pool, and outdoor patio were no exception.
Both my travel partner and I were highly impressed and satisfied with our stay. The location is great, very close to the university/hospital, downtown, and right by i85.
By far the cleanest and quietest hotel I've stayed at for quite some time.
HB
Heather Brooks
Dec 18, 2025
5.0
I have stayed at this hotel multiple times over the past few months. Here’s what I love: it’s quiet in the rooms, the breakfast is super solid, it’s clean, they have movie channels on the TV, there are options for both bathtubs or roll-in showers in the room depending on what you need, everything is new and works well, and the staff is really nice!
I’ve also traveled here with dogs and they liked it as well. The quietness of the hotel again was a huge bonus for making them feel more calm in an unknown place.
The location isn’t the most idyllic. But it is pretty well situated for anything you need to do in Durham. There are also several great hiking trails nearby. The Eno Quarry trailhead and Duke Forest are a five minute drive away.
And the cherry on top for me is that I left an iPhone there. I got a call from the front desk letting me know. This is not my first time leaving a device at a hotel but this is my first time having the hotel initiate reaching out to me. They are sending me a link so that I can pay for postage for them to mail it back. I’m so impressed!