Brand Certified
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
4.6(676 reviews)
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
Business Details
4250 Midamerica Lane, St. Louis, MO
63129, United States
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
(314) 894-0700
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
https://www.ihg.com/holidayinnexpress/hotels/us/en/mehlville/stlml/hoteldetail
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
About
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
HotelWedding VenueBusiness Meeting LocationsHoliday Inn Express
Welcome to the new Holiday Inn Express & Suites St. Louis South I-55!
South St. Louis's newest and most modern Holiday Inn Express Hotel nestled within a growing development at the intersection of Butler Hill Road & I-55 just one mile south of I-270/255 with access to everything St. Louis has to offer. The hotel is just 14 miles directly south of Downtown St. Louis and located at exit #195 from I-55.
Business travelers will benefit from our central location with easy on/off access to I-55 that offers access to the different areas of St. Louis within minutes. The hotel complex includes the Barnes-Jewish Siteman Cancer Center & Mercy Health. We are just minutes from Metlife, Anhueser Busch, Cigna and the National Cemetary Association.
Our non smoking Holiday Inn Express & Suites St. Louis I-55 hotel is very convenient to guests visiting Busch Stadium, Gateway Arch, Grant's Farm, Magic House, St. Louis Science Center, St. Louis Zoo, Forest Park, River City Casino and much more!
Hotel Guests can enjoy an array of amenities including guest room suites, Indoor Pool, Suite Shop, Two Meeting Rooms, Complimentary Express Start Breakfast, Complimentary High Speed Wired & Wireless Internet, Comfortable Great Room with Outdoor Patio and warm Cookies & Milk served nightly.
Guests will enjoy our midwest hospitality in South St. Louis. Our goal is to make every guest feel at home so that we exceed all of their expectations!
Location
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
Holiday Inn Express & Suites St. Louis South - I-55 by IHG
4250 Midamerica Lane, St. Louis, MO
63129, United States
Hours
Certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG • Apr 26, 2026
MondayOpen 24 hours
TuesdayOpen 24 hours
WednesdayOpen 24 hours
ThursdayOpen 24 hours
FridayOpen 24 hours
SaturdayOpen 24 hours
SundayOpen 24 hours
Reviews
4.6
676 reviews
5 stars
503
4 stars
123
3 stars
30
2 stars7
1 star
13
- CMCheavin Milam4 days ago5.0An absolutely fantastic place to stay. Very clean, spacious. The pool was fun. The Gym had everything for a grant workout. Both were clean and well maintained. Having freshly baked cookies and milk was a surprising bonus. Staff is friendly and accommodating. The breakfast was also a great experience. Delicious and well stocked items. We will stay here again.
- RKRosala KrichbaumApr 22, 20265.0Great place! Very clean and the staff were extremely helpful and kind.
- DMDenise MorganApr 17, 20265.0Our experience at the Holiday Inn Express St. Louis South I‑55 was outstanding from the moment we walked through the doors. Krystal, the hotel manager, and her entire staff went above and beyond to make our stay exceptional. We were greeted by Jessica with genuine warmth and hospitality — the kind of welcome that immediately sets the tone for a great visit. The room was spotless, the pool area was clean and inviting, and every part of the hotel felt well cared for. What truly stood out was the extra attention the staff gave to ensure we were comfortable and had everything we needed. From small thoughtful touches to the unexpected treats like milk and cookies, they made us feel valued and at home. This hotel delivers true 5‑star service in every way. We will absolutely be returning.
- MSMandee SmithApr 15, 20265.0great hotel. Great friendly staff! Morning breakfast staff were very friendly and efficient!
- BCBrian CurrinApr 8, 20264.0Clean comfortable rooms. Very nice staff. The breakfast is good and the staff kept the food full. Every night there was a hour when they had cold milk and warm cookies in the lobby. We would gladly stay here again.
Frequently Asked Questions About Holiday Inn Express & Suites St. Louis South - I-55 by IHG
What time is check-in and check-out at Holiday Inn Express & Suites St. Louis South - I-55?
Check-in time is 3:00 PM and check-out time is 11:00 AM.
Is breakfast included during the stay?
Yes, a complimentary Express Start breakfast with buffet options is available for free.
Does the hotel provide free Wi-Fi access?
Yes, free Wi-Fi is available in public areas of the hotel.
Is the Holiday Inn Express & Suites St. Louis South - I-55 accessible for guests with mobility needs?
Yes, the hotel offers accessible parking and is mobility accessible with elevator access.
Are pets allowed at the hotel?
No, pets including cats and dogs are not allowed at this property.
What kind of fitness facilities does the hotel provide?
The hotel offers a free fitness center equipped with elliptical machines, treadmills, and free weights.
Are there any meeting or business facilities available?
Yes, the hotel features two meeting rooms and a business center for guest use.
Is there on-site baggage storage and housekeeping services?
Yes, baggage storage is available and housekeeping services are provided daily.
What nearby medical facilities are close to the hotel?
Nearby medical facilities include Mercy Family Physicians, Mercy Clinic OB/Gyn - Butler Hill, Mercy Clinic Primary Care - Butler Hill, and Barnes-Jewish Heart and Vascular Center.
What dining options are available near the hotel for a quick meal?
Nearby dining options include Taco Bell, Pizza Hut Express, Popeyes® Louisiana Kitchen, and Burger King for fast-food and casual meals.
Where can guests fuel their vehicles or find convenience stores near Holiday Inn Express & Suites St. Louis South - I-55?
Guests can find gas stations and convenience stores such as Phillips 66 Gas, Petro Mart, Rocket, and another Phillips 66 nearby for fuel and supplies.
Brand Certified Facts from Holiday Inn Express & Suites St. Louis South - I-55 by IHG
This information is certified by Holiday Inn Express & Suites St. Louis South - I-55 by IHG and published from the brand's official system of record. Data is distributed through an enterprise-grade knowledge management platform. Learn more about our data sources
Certified April 26, 2026Yext Knowledge Graph
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