HotelWedding VenueBusiness Meeting LocationsConference CenterHoliday Inn
Experience the charm of St. Louis at the renovated Holiday Inn St Louis SW - Route 66, a hotel blending utmost comfort with a prime location and exceptional service to provide an unforgettable stay.
Located on historic Route 66 at highways I-44 and I-270, just 20 minutes from St. Louis Lambert International Airport, we offer easy access to top St. Louis attractions like the Gateway Arch, Missouri Botanical Garden, and the St. Louis Zoo. Catch a St. Louis Cardinals game at Busch Stadium, and visit the Magic House, St. Louis Science Center, Six Flags, or World Wide Technology Soccer Park. Business travelers appreciate proximity to companies like Maritz and Harris-Stowe and top medical centers like Barnes-Jewish Hospital, St. Louis Children's Hospital, SSM Health, and Mercy Hospital.
Enjoy top amenities like a resort-style outdoor pool with luxury cabanas and a state-of-the-art Fitness Center. Relax by our fire pit with a cocktail or play yard games with family or friends. Savor delicious dining at our award-winning steakhouse, Twisted Tree Steakhouse, plus breakfast at Wakey Wakey Breakfast Place and cocktails at Luxe Libations: The Lounge by Twisted Tree. From our elegant Sunset Event Center venues to complimentary parking, free Wi-Fi, and spacious rooms and suites, we are the ideal choice for an exciting and enjoyable stay in St. Louis.
Many customers praised the friendly and helpful staff, particularly mentioning individuals like Caroline and Mark for their exceptional service.
Cleanliness
Overall, guests found the hotel clean, although some reported issues with specific rooms not being spotless.
Amenities
The hotel features a nice pool area, a well-equipped gym, and an attached restaurant that received positive feedback for its food.
Room Quality
While many guests appreciated the updated rooms, some noted that bathrooms were small and there were issues with noise from adjoining rooms.
Location
The hotel is well-located near shopping and dining options, making it convenient for guests.
BF
Brian Fole
2 days ago
1.0
Came here with my family and tried to speak with the manager of this location about accommodatios for my child with down syndrome. Ashley seemed to not care at all. She was at the front desk talking with someone about her wedding plans and seemed to dismiss all of my concerns. My child is very sensitive to these type of situations. As a manager, please show more compassion. Everyone else seemed very pleasant.
KL
Kellie Lohmeyer
Jan 1, 2026
5.0
Also, their conference spaces and setups are excellent! I personally LOVED the Christmas decorations this year. Previous years they didn't have any decorations.
KL
Kenzie Lake
Dec 29, 2025
5.0
Honestly the best hotel I've stayed at in my life. Staff was super friendly, we have some favorite ladies, I hope they see this! They made our stay so wonderful! I highly recommend staying here!
DM
Dave M
Dec 25, 2025
5.0
Easily our favorite Holiday Inn! Updated rooms that are very nice, excellent front desk staff, lots of parking, and a great location. A fireplace and large-screen televisions in the lobby, a good gym with a lot of options, and an outstanding pool area. Plus, an attached lounge and restaurant. The hotel is professionally themed with Route 66 decorations. We highly recommend this hotel.
RH
Robert Hom
Dec 9, 2025
5.0
This Holiday inn is located towards the Southwest of St Louis which seems to be a safer area with a lot of shopping and food surrounding it. There seems to be a plaza right across the street with good food options.
The rooms were really clean and the bed was really comfortable. The vibe of the place seems to focus on route 66.
My room had the view of the pool which actually looked really nice. I was there during cold season so there wasn't really much going on at the pool scene.
There is a really nice restaurant and bar in the lobby area which has some pretty awesome food if you don't want to leave the hotel itself.
The staff is really nice and helpful and was able to answer most of my questions or actually all of my questions whenever I approached them. There's a conference room area which I believe is used for small conventions.
Overall, I would stay here again if I'm ever in the St Louis area. But, I highly doubt I'll ever go back. π
Frequently Asked Questions About Holiday Inn St Louis SW - Route 66 by IHG
Are there business-friendly amenities at Holiday Inn St Louis SW β Route 66?
Yes, Holiday Inn St Louis SW β Route 66 includes a 24-hour Business Center with computers, printers, fax services, and shipping optionsβideal for business travelers and remote work needs.
Is the hotel pet-friendly?
Yes, the hotel is pet-friendly, welcoming your furry friends with comfortable accommodations. There are designated pet-friendly rooms and nearby parks for easy walks.
What are the dining options at the hotel?
Guests can dine at our on-site restaurant, which offers a variety of American dishes throughout the day. There's also a bar for evening drinks and snacks. Room service is available for those who prefer to dine in the comfort of their room.
Does the hotel have event spaces?
Yes, the hotel offers versatile event spaces, including meeting rooms equipped with modern audiovisual technology. These spaces are ideal for corporate meetings, conferences, weddings, and other social gatherings. Our dedicated event planning team is on hand to assist with every detail.
Is there free parking available?
Absolutely. The hotel provides complimentary on-site parking for all guests, with ample space for cars, SUVs, and even larger vehicles like RVs and buses. This convenience makes it easy for guests to explore the St. Louis area without worrying about parking fees or availability.
Does Holiday Inn St Louis SW β Route 66 offer meeting/event spaces beyond banquet halls?
Yes, Holiday Inn St Louis SW β Route 66 provides over 15,500 sq ft of flexible event space, including the Sunset Ballroom and seven breakout rooms equipped with A/V tech, ideal for corporate events or social functions.
Can guests at Holiday Inn St Louis SW β Route 66 enjoy a firepit or outdoor lounge area?
Yes, Holiday Inn St Louis SW β Route 66 features a cozy outdoor firepit lounge area right off the outdoor pool, perfect for relaxing evenings or casual socializing.
Are the rooms at Holiday Inn St Louis SW β Route 66 equipped with mini-fridges and microwaves?
Yes, all guest rooms at Holiday Inn St Louis SW β Route 66 feature a mini fridge and microwave to ensure guests have convenient in-room dining options.
Does Holiday Inn St Louis SW β Route 66 provide dry-cleaning and laundry services?
Yes, guests at Holiday Inn St Louis SW β Route 66 have access to on-site self-service laundry facilities and dry cleaning/laundry valet options for added convenience.
What are the check-in and check-out times at Holiday Inn St Louis SW β Route 66?
Check-in time is at 3:00 PM and check-out time is at 11:00 AM at Holiday Inn St Louis SW β Route 66.
Does the hotel accommodate guests with pets?
Yes, Holiday Inn St Louis SW β Route 66 is pet-friendly and welcomes both cats and dogs.
Are there fitness facilities available for guests?
Yes, the hotel offers a fitness center with free access including free weights and a treadmill.
Is there parking available for guests, and is it free?
Yes, the hotel provides free self-parking with accessible parking spaces available.
Does Holiday Inn St Louis SW β Route 66 provide business and event amenities?
Yes, the hotel features a 24-hour business center, seven meeting rooms, over 15,500 sq ft of flexible event space including the Sunset Ballroom, and a dedicated event planning team.
What dining options are available at the hotel?
Guests can enjoy two on-site restaurants including the award-winning Twisted Tree Steakhouse, the Wakey Wakey Breakfast Place for breakfast, and Luxe Libations bar for cocktails and snacks. Room service is also available.
Are there any nearby car rental agencies that guests can use?
Yes, guests can conveniently find Budget Car Rental and Avis Car Rental near the hotel, making it easy to explore St. Louis by car.
What nearby family-friendly attractions can guests visit?
Guests can visit nearby attractions such as the St. Louis Zoo, Missouri Botanical Garden, Magic House, St. Louis Science Center, and Six Flags, all within easy reach from the hotel.
How can guests use nearby dining options around the hotel?
Besides the hotelβs own dining, guests can explore nearby restaurants like Steak 'n Shake for casual dining, Lion's Choice for fast American food, Wingstop for chicken wings, and Yogurtland for desserts, enriching their local food experience.
Is there free Wi-Fi available at Holiday Inn St Louis SW β Route 66?
Yes, free Wi-Fi is available throughout the hotel's public areas for all guests to stay connected.