Welcome to Our Cape Girardeau Hotel. Just off I- 55 at exit 96, the Holiday Inn Express Hotel & Suites Cape Girardeau I-55 offers hotel guests 102 spacious, contemporary suites. Vacation and business guests alike choose these accommodations for a comfortable and convenient stay. Our Cape Girardeau, Missouri hotel is just minutes from Southeast Missouri State University, where guests are encouraged to cheer on the Redhawks in football and basketball. We're also only 10 miles from Trail of Tears State Park, so families can enjoy picnics, hiking, biking and fishing. Be sure to stop by our Old Downtown area where you will not only enjoy a variety of shops and restaurants, but you can enjoy the great view of the Mississippi River. Business travelers appreciate our Cape Girardeau, Missouri hotel's convenient location close to St. Francis Hospital, Southeast Missouri Hospital, Doctors Park, the Show Me Center, Procter & Gamble, Mondi, Shawnee Park and Biokyowa. We provide two spacious meeting rooms, as well, which feature A/V equipment ideal for business functions or special events. With the help of our professional staff, your event can be a success. At our Girardeau hotel, we know it's the extra perks that make your stay unforgettable. We provide an indoor pool and well-equipped fitness center to help you relax and unwind. Be sure to stop by our breakfast bar each morning, too, for biscuits, eggs, fruit and our signature cinnamon rolls. We look forward to your next visit!
Location
Holiday Inn Express & Suites Cape Girardeau I-55 by IHG
Most customers praised the cleanliness of the rooms and facilities, although a few reported issues with room cleanliness during their stay.
Staff Service
The staff received numerous compliments for being friendly, helpful, and attentive, although there were isolated reports of unhelpful interactions.
Breakfast Quality
Guests enjoyed the breakfast offerings, noting a good variety and quality, with some highlighting unique features like cookies and milk in the evening.
Noise Issues
Several reviews mentioned noise disturbances from other guests or external sources, impacting the overall comfort of their stay.
Location
The hotel is conveniently located near restaurants and shopping, which was appreciated by many guests.
AG
Amanda Greene
Nov 9, 2025
5.0
Everything about this hotel, I love. The staff are so friendly and understanding of my kids, nothing like the partner site in sikeston, MO. My kids and I love the manager Mrs. Susan. She is a sweetheart and makes you feel welcome, as well as gives recommendations for things to do around town. There are all kinds of families with kids, sports teams, and a diverse number of people. I have never felt unwelcomed during my extended stay with my four kids. I can not praise this site enough. I hope that everyone and Mrs.Susan gets the recognition they deserve from the front desk to housekeeping. Everyone is wonderful. The breakfast is also good. I'd give it a 100 stars, and I appreciate them for making it feel at home during my home buying process. Extremely kid friendly.
JL
Julie Lalla
Nov 8, 2025
5.0
Very clean, friendly staff, everything was modern and updated.
JM
John McDowell
Oct 25, 2025
5.0
Ladies at the front were super helpful. I forgot my toothbrush and they had a replacement for me.
OF
Oscar Figueroa
Oct 23, 2025
5.0
Big, clean rooms, mini kitchen, good continental breakfast, excellent staff
AG
Andrew Green
Oct 14, 2025
5.0
This is one of the nicest Holiday Inn Express locations I've ever stayed at. However it is worth noting that there is no hot tub as shown in the pictures on google. I attached a photo showing the hot tub filled in and now used as a patio area.
Frequently Asked Questions About Holiday Inn Express & Suites Cape Girardeau I-55 by IHG
What are the check-in and check-out times at Holiday Inn Express & Suites Cape Girardeau I-55?
Check-in time is at 3:00 PM and check-out time is at 11:00 AM.
Is breakfast included during my stay at this hotel?
Yes, a free buffet breakfast is available for all guests.
Does the hotel offer free Wi-Fi?
Yes, free Wi-Fi is available in public areas throughout the hotel.
Are there fitness facilities available at the hotel?
Yes, the hotel has a fitness center with elliptical machines, free weights, and treadmills available for free use.
Is parking available at the Holiday Inn Express & Suites Cape Girardeau I-55?
Yes, free parking is available for all guests.
Does the hotel provide accommodations accessible for guests with mobility challenges?
Yes, the hotel is mobility accessible and offers accessible parking and an elevator.
Are pets allowed at the hotel?
No, pets including cats and dogs are not allowed on the property.
What nearby attractions can I visit while staying at the Holiday Inn Express & Suites Cape Girardeau I-55?
Guests can visit Southeast Missouri State University to enjoy sports events, explore the Old Downtown area for shops and restaurants along the Mississippi River, and spend time outdoors at Trail of Tears State Park with activities such as hiking, biking, and fishing.
Are there any nearby dining options around the hotel?
Yes, nearby dining options include Olive Garden for Italian cuisine, Popeyes® Louisiana Kitchen for fast food, Panera Bread for coffee and bakery items, Red Lobster for seafood, and Cracker Barrel Old Country Store for American and barbecue dishes.
Can I hold business meetings or events at the Holiday Inn Express & Suites Cape Girardeau I-55?
Yes, the hotel has two spacious meeting rooms equipped with audio/visual equipment, suitable for business functions and special events.