H-E-B Pharmacy was ranked #1 in customer satisfaction for supermarket pharmacies by J.D. Power for the 3rd year in a row in 2023. At your nearby H-E-B Pharmacy located at 4800 Main Street in Frisco, the health and safety of Texans is our top priority. As a trusted source for all routine childhood and adult immunizations, H-E-B Pharmacy is also a provider for COVID 19 vaccine. H-E-B is proud to continue our long-term tradition of taking care of Texans.
Pseudaphedrine HEB 12 hour (20 ct)
$5 ... Competition $14.99
The only great decongestant $5
PM
Paul Mitchell
Sep 12, 2025
5.0
Great service
TL
T Leuci
Nov 16, 2023
3.0
My experience has been mostly good there but here’s some constructive criticism for H‑E‑B pharmacy. If you don’t have my prescription in stock and it’s backordered, please consider calling to let me know it’s not available. It’s kind of dangerous to not have life saving medications available when your customers arrive to pick them up.
TH
Trinity Howland
May 14, 2023
5.0
This pharmacy staff is some of the friendliest, easiest pharmacy techs I have ever dealt with. They are so understanding and helpful when it comes to medication shortage. Every other pharmacy in the area was rude and unhelpful, but HEB gave me multiple options to help me get my medication and I appreciate them so much. They are my new go-to pharmacy!
H-E-B Pharmacy is located at 4800 Main Street, Frisco, TX 75033, USA.
What are the operating hours of H-E-B Pharmacy?
H-E-B Pharmacy is open Monday to Friday from 8:00 AM to 8:00 PM, Saturday from 9:00 AM to 6:00 PM, and Sunday from 10:00 AM to 5:00 PM.
Does H-E-B Pharmacy offer COVID-19 vaccinations?
Yes, H-E-B Pharmacy provides COVID-19 vaccines along with routine childhood and adult immunizations.
What payment options are accepted at H-E-B Pharmacy?
H-E-B Pharmacy accepts American Express, Discover, Mastercard, Visa, Apple Pay, Android Pay, Samsung Pay, cash, check, and contactless payments.
Is there a drive-through service available at H-E-B Pharmacy?
Yes, H-E-B Pharmacy offers a drive-through service for customer convenience.
Can I get free Wi-Fi at H-E-B Pharmacy?
Yes, H-E-B Pharmacy offers free Wi-Fi for customers.
Are there wheelchair accessible facilities at H-E-B Pharmacy?
Yes, the pharmacy has wheelchair accessible parking and restrooms.
What nearby places can customers visit before or after their pharmacy visit?
Customers can visit nearby places like True Texas BBQ for a meal, Smoothie King for a refreshing drink, and Panera Bread for bakery and café offerings.
Are there convenient financial services close to H-E-B Pharmacy?
Yes, nearby financial services include Coin Cloud Bitcoin ATM, LibertyX Bitcoin ATM, CVS ATM, and EECU Financial Center for banking and currency exchange needs.
Where can I find other health-related services near H-E-B Pharmacy?
Nearby health services include Frisco West Animal Medical Center, Aesthetic General Dentistry of Frisco, Frazier Family Orthodontics, Premier Foot and Ankle, ChiroSport Specialists of Frisco, and Legacy ER & Urgent Care.
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