Chronic kidney disease is a common condition that involves malfunction of the kidneys, which filter the blood and keep them free of waste and other substances. This condition can affect anyone, but is more common in those with diabetes, high blood pressure or a family history of kidney disease, although it may also be caused by infections or urinary blockages. If left untreated, it may lead to kidney failure. Patients with CKD may not notice any symptoms during the early stages of this condition, although those in more advanced stages may experience: Fatigue Difficulty concentrating Lack of appetite Muscle cramping Dry, itchy skin Frequent urination Once CKD is diagnosed it is important to determine the level of kidney function. The National Kidney Foundation has identified 6 stages of chronic kidney disease. Each stage represents a level of kidney function as defined by a creatinine clearance: Stage 1 CrCl > 90 Stage 2 CrCl 60-89 Stage 3 CrCl 30-59 Stage 4 CrCl 15-29 Stage 5 CrCl <15 Stage 6 End Stage Renal Disease Initial treatment for CKD involves managing the underlying condition which will usually improve kidney function as a result. It is important for patients to eat a healthy, balanced diet and exercise regularly, as well as remain hydrated and avoid smoking. Depending on the severity of your condition, your doctor may prescribe medication for high blood pressure, dialysis or kidney transplant to treat your condition and maintain or improve the function of the kidneys.