H-E-B Pharmacy was ranked #1 in customer satisfaction for supermarket pharmacies by J.D. Power for the 3rd year in a row in 2023. At your nearby H-E-B Pharmacy located at 20935 US Highway 281 North in San Antonio, the health and safety of Texans is our top priority. As a trusted source for all routine childhood and adult immunizations, H-E-B Pharmacy is also a provider for COVID 19 vaccine. H-E-B is proud to continue our long-term tradition of taking care of Texans.
Best groceries store in the city. Always stocked up and staffs are always friendly
KC
K C
Jan 4, 2026
1.0
Horrendous and the customer service is non existent, always a nightmare due to long waits and the staff acts miserable. I wish the manager would see this and manage correctly bc it’s never the staffs fault it’s the manager who tolerates it.
CG
Charlene Gieptner
Nov 14, 2025
5.0
EXCELLENT!!!!!! So very nice and always willing to help and explain all about the medications if they are new to you.
Thank you for always having such a nice staff.
JN
Jamie Nickles
Nov 18, 2022
1.0
WORST EXPERIENCE EVER!!!! Got there @11:30 and they said they would call in 2 hours because they had BOTH my prescriptions and had to make sure with my doctor even though he was the one to give me the prescriptions. THEY NEVER CALLED. So i went back 4 hours later and they still hadn't called my doctor and so they had me wait for them to call and they told me that they could give me the prescription only ONE though. They then told me that they didn't have the other prescription even though they told me they had both. Then told me to go to another H-E-B.
Where can I find the latest H-E-B Pharmacy news regarding the COVID-19 Vaccine?
Please visit https://vaccine.heb.com/ to learn more about the vaccine, including current vaccine phases and answers to Frequently Asked Questions
Do H-E-B Pharmacies accept walk-ins for COVID-19 and flu vaccines?
COVID-19 and flu vaccines are available on both a walk-in or appointment basis
What are the operating hours of H-E-B Pharmacy at 20935 US Highway 281 North?
H-E-B Pharmacy is open Monday to Friday from 8:00 AM to 8:00 PM, Saturday from 9:00 AM to 6:00 PM, and Sunday from 10:00 AM to 5:00 PM.
Does H-E-B Pharmacy offer COVID-19 and flu vaccines, and do they accept walk-ins?
Yes, H-E-B Pharmacy provides COVID-19 and flu vaccines and accepts both walk-in and appointment visits for these vaccinations.
Is delivery or in-store pickup available at H-E-B Pharmacy?
Yes, H-E-B Pharmacy offers both in-store pickup and delivery services for prescriptions and health products.
What payment options does H-E-B Pharmacy accept?
H-E-B Pharmacy accepts American Express, Android Pay, Apple Pay, cash, check, contactless payment, Discover, MasterCard, Samsung Pay, and Visa.
How can I find more information on H-E-B Pharmacy services online?
You can visit https://www.heb.com/pharmacy/common/landing to view all H-E-B Pharmacy services and information.
Is H-E-B Pharmacy wheelchair accessible and does it provide free Wi-Fi?
Yes, H-E-B Pharmacy has wheelchair accessible parking and offers free Wi-Fi to customers.
Where can I get cash or Bitcoin ATM services near H-E-B Pharmacy?
Nearby ATMs include Margo Bitcoin ATM, Coin Cloud DCM, Coinme, and an H-E-B ATM, providing cash and cryptocurrency services conveniently close to the pharmacy.
What dining options are available near H-E-B Pharmacy for a quick meal or smoothie?
You can visit Jamba for smoothies and sandwiches, Honeysuckle White for fast food, or Cactus Coffee Shop for breakfast and drinks, all located nearby the pharmacy.
Are there medical or urgent care facilities near H-E-B Pharmacy?
Yes, RediClinic Stone Ridge is a nearby urgent care clinic and medical center that you can visit before or after your pharmacy visit.
What makes H-E-B Pharmacy stand out according to customer satisfaction?
H-E-B Pharmacy was ranked #1 in customer satisfaction for supermarket pharmacies by J.D. Power for the third consecutive year in 2023, highlighting its dedication to quality service and care.
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