Business Details
About
PharmacyPharmaciesPrescription DrugsDrug StoreCOVID-19 Vaccine Location
At your nearby Melissa H-E-B Pharmacy located at Central Expressway and Hwy 121, the health and safety of Texans is our top priority. As a trusted source for all routine childhood and adult immunizations, H-E-B Pharmacy is also a provider for COVID 19 vaccine. H-E-B is proud to continue our long-term tradition of taking care of Texans. H-E-B Pharmacy was ranked #1 in customer satisfaction for supermarket pharmacies by J.D. Power for the 3rd year in a row in 2023.
Location
Hours
Reviews
3.9
21 reviews
5 stars
15
4 stars0
3 stars0
2 stars
1
1 star
5
- CMCharlene MerrittJan 4, 20265.0Puts customer service and patient care first!
- LCLarry CDec 29, 20255.0The best pharmacy and customer service in Melissa!
- JLJeff LevesqueDec 26, 20251.0Check expiration dates before you checkout. The past 2 times we have gone we ended up with items that were already expired by 3 months.
- JAJanine AkinradewoNov 15, 20255.0I’ve not experienced a nicer team of Pharmacists and techs in the DFW. Everyone is kind, patient and willing to go out of their way to help. I’m so thankful this is our local pharmacy after years of being less than pleased elsewhere.
- EREmily RodenNov 12, 20255.0Has been a great experience since transferring RX’s from Walmart.
Frequently Asked Questions About H-E-B Pharmacy
What are the regular operating hours for H-E-B Pharmacy in Melissa, TX?
H-E-B Pharmacy in Melissa, TX is open Monday to Friday from 8:00 AM to 8:00 PM, Saturday from 9:00 AM to 6:00 PM, and Sunday from 10:00 AM to 5:00 PM.
Does H-E-B Pharmacy offer drive-through service and what are the hours?
Yes, H-E-B Pharmacy offers drive-through service Monday to Friday from 8:00 AM to 8:00 PM, Saturday from 9:00 AM to 6:00 PM, and Sunday from 10:00 AM to 5:00 PM.
What types of payment methods are accepted at H-E-B Pharmacy?
H-E-B Pharmacy accepts American Express, Android Pay, Apple Pay, cash, check, Discover, Mastercard, Samsung Pay, and Visa.
Does H-E-B Pharmacy provide delivery services?
Yes, H-E-B Pharmacy offers delivery services for prescriptions and other pharmacy needs.
What immunization services does the H-E-B Pharmacy in Melissa offer?
H-E-B Pharmacy provides all routine childhood and adult immunizations, including the COVID-19 vaccine.
When did this H-E-B Pharmacy location in Melissa open?
This H-E-B Pharmacy location in Melissa opened on May 14, 2025.
Where is H-E-B Pharmacy located in Melissa, Texas?
H-E-B Pharmacy is located at 1230 Central Expressway, Melissa, TX 75454, USA, near the intersection of Central Expressway and Highway 121.
What are some nearby dining options I can visit before or after going to H-E-B Pharmacy?
Nearby dining options include True Texas BBQ, Murphy's Island barbecue restaurant and food truck, and Jimmy John's fast food restaurant.
Are there any nearby convenience stores or gas stations near H-E-B Pharmacy?
Yes, nearby convenience stores and gas stations include Pruvit Ventures convenience store, H-E-B Fuel gas station, Buc-ee's gas station and bakery, and RaceTrac gas station and convenience store.
Can I find additional health and nutrition stores near H-E-B Pharmacy?
Yes, nearby health and nutrition stores include Make Ready Nutrition, MCM Nutrition, Uforia Science, and SNiP Nutrigenomics—all offering vitamins and supplements.