H-E-B Pharmacy was ranked #1 in customer satisfaction for supermarket pharmacies by J.D. Power for the 3rd year in a row in 2023. At your nearby H-E-B Pharmacy located at 19337 McDonald Street in Lytle, the health and safety of Texans is our top priority. As a trusted source for all routine childhood and adult immunizations, H-E-B Pharmacy is also a provider for COVID 19 vaccine. H-E-B is proud to continue our long-term tradition of taking care of Texans.
I’ll be moving my meds to another pharmacy. On multiple occasions I have been texted that my prescriptions are ready only for parts to be missing or the entire prescription to be missing. Today that happened again except this time they asked me to loop the drive through line again or go inside and wait. Today’s experience took an hour.
Don’t put your prescriptions at the Lytle HEB.
AC
Alicia Chincarini
Feb 20, 2026
1.0
If u are dieing. Need a script folder or bl8bd .this HEB puts there pharmacy customer on hold and will not help answering phone until after. 1 pm so they have an excuse people need immediate meds and yall don't answer phone calls
JS
Jesse Sanchez
Jan 3, 2026
5.0
Been using this pharmacy before it became an heb plus. The staff has been helpful in one way or another in either transferring my prescription to another heb that can fill my prescription or they have done a partial fill to get me out of a bind.
RR
Ro Ro
Nov 9, 2025
1.0
. The female pharmacist is a big bully she makes it difficult for you to fill your prescriptions. Customer service is terrible.
Where can I find the latest H-E-B Pharmacy news regarding the COVID-19 Vaccine?
Please visit https://vaccine.heb.com/ to learn more about the vaccine, including current vaccine phases and answers to Frequently Asked Questions
Do H-E-B Pharmacies accept walk-ins for COVID-19 and flu vaccines?
COVID-19 and flu vaccines are available on both a walk-in or appointment basis
What are the operating hours of H-E-B Pharmacy in Lytle, TX?
H-E-B Pharmacy in Lytle is open Monday through Friday from 8:00 AM to 8:00 PM, Saturdays from 9:00 AM to 6:00 PM, and Sundays from 10:00 AM to 5:00 PM.
Does H-E-B Pharmacy in Lytle offer COVID-19 and flu vaccines?
Yes, H-E-B Pharmacy provides COVID-19 and flu vaccines, which are available on a walk-in or appointment basis.
How can I get the latest updates on COVID-19 vaccines from H-E-B Pharmacy?
You can visit https://vaccine.heb.com/ for the latest vaccine news, phases, and FAQs related to COVID-19 offered by H-E-B Pharmacy.
Does H-E-B Pharmacy offer delivery services for prescriptions?
Yes, H-E-B Pharmacy provides delivery services for prescriptions.
What payment methods are accepted at H-E-B Pharmacy in Lytle?
H-E-B Pharmacy accepts American Express, Mastercard, Visa, Discover, cash, check, Apple Pay, Android Pay, Samsung Pay, and contactless payments.
Where is H-E-B Pharmacy located in Lytle?
H-E-B Pharmacy is located at 19337 McDonald Street, Lytle, TX 78052, United States.
Are appointments required for vaccinations at H-E-B Pharmacy in Lytle?
No, appointments are not required for COVID-19 and flu vaccinations; walk-ins are welcome.
What nearby places can I visit before or after my pharmacy visit at H-E-B Pharmacy?
Nearby you can visit restaurants like Honeysuckle White, Taco Bell, and Whataburger for a meal, or enjoy services at Great Clips salon and Lytle Nail and Spa for beauty treatments.
Is there a grocery store near H-E-B Pharmacy in Lytle for convenient shopping?
Yes, the main H-E-B grocery store and H-E-B Fresh Bites convenience store are nearby, making it easy to combine your pharmacy visit with grocery shopping.
Are there any transportation or travel options near H-E-B Pharmacy in Lytle?
While there is no direct transit station mentioned, nearby places like Days Inn by Wyndham San Antonio Lytle hotel can accommodate travelers visiting the area, and services like Margo Bitcoin ATM and Redbox offer added convenience.
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