Mariano's Pharmacy in ORLAND PARK, IL is staffed with professionals dedicated to helping you lead a healthier life. Protect yourself and your family with vaccinations, medicine and more. Our pharmacists do more than prepare prescription refills and dispense medical supplies; they also offer advice on health topics, perform clinical services, and administer vaccinations, including the Tdap vaccine, measles vaccine, shingles vaccine, flu shots and more.
Need to request a prescription transfer or refill a medication? Our convenient online tools make it easy to manage your prescriptions quickly, simply and on your own schedule.
The pharmacist Mike is amazing very helpful and patient.
BR
Beverly Rieves
Feb 5, 2026
5.0
Very helpful and nice
RN
Roger Nowacki
Jan 28, 2026
5.0
Above and Beyond- for years! TEN Stars!
Pharmacist Mike has taken professional care of our family's needs for years and without fail, has presented a " WE'RE ALL FAMILY" attitude that keeps us coming back. That attitude is also catching on to the rest of the crew. There is no other pharmacy in our that even come close!
Frequently Asked Questions About Mariano's Pharmacy
What types of vaccinations are available at Mariano's Pharmacy in Orland Park?
Mariano's Pharmacy offers various vaccinations including Tdap, HPV, shingles, flu shots, measles, and COVID-19 vaccines (Pfizer, Moderna, Johnson & Johnson).
Do I need an appointment to receive a COVID-19 vaccine at Mariano's Pharmacy?
Yes, a COVID-19 vaccine appointment is required. Upon arrival, proceed to the pharmacy window and inform the attendant of your appointment.
What are the pharmacy hours at Mariano's Pharmacy in Orland Park?
The pharmacy is open Monday through Friday from 9:00 AM to 1:00 PM and 1:30 PM to 8:00 PM; Saturday from 9:00 AM to 1:00 PM and 1:30 PM to 6:00 PM; and Sunday from 10:00 AM to 1:00 PM and 1:30 PM to 5:00 PM.
Can I refill or transfer prescriptions online at Mariano's Pharmacy?
Yes, Mariano's Pharmacy provides convenient online tools for requesting prescription transfers and refills, allowing you to manage your medications easily on your schedule.
What payment methods does Mariano's Pharmacy accept?
They accept credit cards, debit cards, mobile NFC payments, and pay checks. Cash-only payments are not required.
Does Mariano's Pharmacy offer delivery or curbside pickup services?
Yes, Mariano's Pharmacy offers same-day delivery, curbside pickup, and in-store shopping options for your convenience.
Is Mariano's Pharmacy equipped to accommodate customers with disabilities?
Yes, the pharmacy has wheelchair accessible parking, seating, and restrooms to accommodate customers with disabilities.
What nearby grocery stores can I visit along with Mariano's Pharmacy?
You can also visit Mariano's Orland Park grocery store, located nearby, offering groceries alongside pharmacy services for a convenient shopping experience.
Are there restaurants near Mariano's Pharmacy for dining before or after my visit?
Yes, nearby dining options include Granite City Food & Brewery, P.F. Chang's, Chuck Lager America's Tavern, and Crumbl - Orland Park, perfect for enjoying a meal before or after your pharmacy visit.
Where can I find beauty and spa services near Mariano's Pharmacy?
Several beauty salons and spas are nearby, such as Sleek To Perfection, Images Studio Blowout Bar, Mizzus_nikkididthat, Elevated Mane Salon, and Sarah A Esthetics, ideal for a retreat or grooming appointment around your pharmacy visit.
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Certified March 15, 2026Yext Knowledge Graph
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