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Panera Bread Durham welcomes guests to our café with warm hospitality and quality ingredients. We serve a variety of menu favorites for breakfast, lunch, and dinner—including fresh coffee, bakery items, salads, soups, and sandwiches—crafted to help you feel good about what you’re enjoying. Whether you’re dining in while enjoying complimentary Wi‑Fi, ordering online for Rapid Pick‑Up, enjoying delivery, or planning catering for a large group, Panera Bread Durham is here to make your day a little better. Food as it should be.
Explore offerings from Panera Bread on 10 Duke Medicine Circle in Durham, with popular sandwiches, soups & mac, salads, and pastries & sweets available at this location.
Smoked, pulled chicken raised without antibiotics, smoked Gouda, fresh avocado and cilantro, zesty sweet Peppadew™ peppers and chipotle sauce on Black Pepper Focaccia.
Smoked, pulled chicken, fresh mozzarella, vine-ripened tomatoes, red onions, fresh basil, chipotle aioli, salt and pepper on our Black Pepper Focaccia.
Black Forest ham, soppressata, provolone, romaine, red onion, sliced pepperoncini peppers, garlic aioli, and Greek dressing on our toasted French Baguette.
Melty fresh mozzarella, vine-ripened tomatoes, chopped basil, crisp romaine & lettuce blend, sprinkled with salt and pepper, and balsamic vinaigrette and garlic aioli drizzle on our Ciabatta.
Oven-roasted turkey breast, applewood smoked bacon with aged white cheddar, crisp mixed greens, vine-ripened tomatoes, sprinkled with salt and pepper, and our Signature Bravo sauce drizzle on our Tomato Basil Miche.
Oven roasted turkey breast, aged white cheddar, crisp mixed greens, vine-ripened tomatoes, red onions, garlic aioli, salt and pepper on our Country Rustic Sourdough.
A rich chunky chili with beef, kidney beans, fire roasted tomatoes and green chili peppers, simmered in a broth flavored with a blend of chilis, and cilantro.
Tender pieces of white-meat chicken simmered in a rich, perfectly seasoned homestyle chicken bone broth with curly egg noodles, sliced carrots, celery and herbs.
Vine-ripened pear tomatoes pureed with fresh cream for a velvety smooth flavor accented by hints of red pepper and oregano and topped with black pepper and sea salt croutons.
Romaine and crisp mixed greens tossed in a sweet white balsamic vinaigrette, topped with grilled chicken, grape tomatoes, red onions, toasted pecan pieces, feta, and apple chips.
Romaine and crisp mixed greens tossed in Green Goddess dressing, topped with grilled chicken, grape tomatoes, and pickled red onions, fresh avocado, applewood smoked bacon and a hard-boiled egg.
Romaine tossed in ranch dressing, with grilled chicken and drizzled with chipotle aioli, topped with fresh avocado, grape tomatoes, roasted corn, fresh cilantro, and blue corn tortilla strips.
Romaine and crisp mixed greens tossed in Greek Dressing, topped with our whole grain blend, grilled chicken, hummus, feta, red onions, zesty sweet Peppadew peppers, sliced cucumbers, and a sprinkle of shawarma seasoning.
Romaine and crisp mixed greens tossed in Greek Dressing, topped with our whole grain blend, hummus, feta, red onions, zesty sweet Peppadew peppers, sliced cucumbers, and a sprinkle of shawarma seasoning.
Romaine tossed in Greek dressing, topped with grilled chicken, grape tomatoes, feta, sliced cucumbers, red onions, kalamata olives, sliced pepperoncini peppers, salt and pepper.
Romaine tossed in Greek dressing, topped with grape tomatoes, feta, sliced cucumbers, red onions, kalamata olives, sliced pepperoncini peppers, salt and pepper.
Romaine and crisp mixed greens tossed in ranch dressing, topped with grape tomatoes, pickled red onions, applewood smoked bacon, feta, and a hard-boiled egg.
A salty, chocolaty, caramel confection big enough to share. A large cookie with semi-sweet chocolate, milk chocolate, caramel pieces, pretzels and then topped with flake salt.
Soft and smooth with hints of citrus, roasted nut and chocolate. A blend of Central and South American beans. Light bodied with a bright sweetness. Freshly ground in cafes.
Subtle nutty tones with wonderful coffee flavor. Serves 10. Brewed fresh, so please allow additional 15 min./tote to prepare your order. 120 fl oz per tote.
Rich, bold and full-bodied, balanced with a smoky accent and sweet chocolate notes. Harvested from Central and South America. Serves 10. 120 fl oz per tote.
Carefully roasted from Arabica beans and freshly brewed. Brewed fresh, so please allow additional 15 min./tote to prepare your order. Serves 10. 120 fl oz per tote.
Smoked, pulled chicken, scrambled egg, white cheddar, zesty sweet Peppadew peppers, fresh avocado and cilantro, salt and pepper, and chipotle aioli on Ciabatta.
A meal to feed the whole family, including 4 half sandwiches, 1 whole salad, 1 group soup, 1 whole French baguette and 4 Chocolate Chipper Cookies. Serves 4-6.
A meal to feed the whole family, including 4 half sandwiches, 1 whole salad, 1 group soup, 1 whole French baguette and 4 Chocolate Chipper Cookies. Serves 4-6.
Explore offerings from Panera Bread on 10 Duke Medicine Circle in Durham, with popular we’re here to help when and where you need us. available at this location.
We deliver your Panera favorites right to your door with contactless delivery. Just tell us where to leave your meal in the “Delivery Instructions” box when placing your order.
Panera pizza is here! Unbox the new flatbread pizzas in three varieties: margherita, chipotle chicken & bacon, and cheese. Pick it up, have it delivered, or grab it through the drive through for lunch or dinner.
Wasn't familiar with Panera. Bought a bagel with cream cheese. They delivered an uncut, cold bagel. As I was cutting through the bagel, a young lady said that they would have done that for me. I asked why the bagel was cold, she replied I had to ask for a toasted and sliced bagel. When she realized I didn't know, she went and got me a toasted and sliced bagel. Service above and beyond these days. ❤️
ME
mud exclusive
May 14, 2026
1.0
Food was good. Service extremely slow. They want u in and out. Get msg foodbid ready. Went to counter and they hadn't started making it yet. This was 6 min after I paid. Nevwr going there again I will bring my own food to hospital.
CJ
Cinor Jones
Apr 25, 2026
3.0
The food was good. The customer service and hygiene/upkeep of the store was very inconsistent.
JL
Josh Lawrence
Jul 20, 2024
5.0
The best Panera location I’ve been to! Coffee is always out, tastes great. I’ve never had a mistake on any of my orders, and the food always tastes fresh. The staff are super friendly and helpful, and it’s clear from how clean and nice everything is that they all work hard. Highly recommend!!!!
Does Panera Bread at 10 Duke Medicine Circle accept reservations?
No, this Panera Bread location does not accept reservations.
What types of meals are served at Panera Bread in Durham?
They serve breakfast, lunch, brunch, and dinner.
What are the opening hours for Panera Bread during the weekdays?
Panera Bread is open from 6:00 AM to 8:00 PM Monday through Friday.
Is delivery available at the Panera Bread on Duke Medicine Circle?
No, this location does not offer delivery services.
Can I use Rapid Pick-Up or order online for quick service at this Panera Bread?
Yes, you can order online using Rapid Pick-Up to grab your order quickly.
What types of payment does Panera Bread accept?
They accept American Express, Cash, Discover, MasterCard, and Visa.
Is there drive-thru or curbside pickup available at this Panera Bread?
No, this location does not have a drive-thru or curbside pickup.
What are some nearby medical facilities around Panera Bread at 10 Duke Medicine Circle?
Nearby medical facilities include Duke Medicine Pavilion, Duke Health, Duke Emergency Department, and Duke Cancer Center, which makes it convenient for visitors or staff to grab meals before or after appointments.
Are there nearby cafes or restaurants to Panera Bread in Durham for a variety of dining options?
Yes, Tropical Smoothie Cafe is nearby, offering smoothie and café options. Visitors can enjoy different dining choices in the area.
How can the nearby Duke Medicine Pavilion Imaging and Cardiac Diagnostic units be helpful when visiting Panera Bread?
These nearby diagnostic centers are convenient for patients and staff to visit Panera Bread for meals or coffee during their appointments or workday.
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