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Panera Bread Indianapolis welcomes guests to our café with warm hospitality and quality ingredients. We serve a variety of menu favorites for breakfast, lunch, and dinner—including fresh coffee, bakery items, salads, soups, and sandwiches—crafted to help you feel good about what you’re enjoying. Whether you’re dining in while enjoying complimentary Wi‑Fi, ordering online for Rapid Pick‑Up, enjoying delivery, or planning catering for a large group, Panera Bread Indianapolis is here to make your day a little better. Food as it should be.
Explore offerings from Panera Bread on 5335 E Southport Road in Indianapolis, with popular sandwiches, soups & mac, salads, and pastries & sweets available at this location.
Smoked, pulled chicken raised without antibiotics, smoked Gouda, fresh avocado and cilantro, zesty sweet Peppadew™ peppers and chipotle sauce on Black Pepper Focaccia.
Smoked, pulled chicken, fresh mozzarella, vine-ripened tomatoes, red onions, fresh basil, chipotle aioli, salt and pepper on our Black Pepper Focaccia.
Black Forest ham, soppressata, provolone, romaine, red onion, sliced pepperoncini peppers, garlic aioli, and Greek dressing on our toasted French Baguette.
Melty fresh mozzarella, vine-ripened tomatoes, chopped basil, crisp romaine & lettuce blend, sprinkled with salt and pepper, and balsamic vinaigrette and garlic aioli drizzle on our Ciabatta.
Oven-roasted turkey breast, applewood smoked bacon with aged white cheddar, crisp mixed greens, vine-ripened tomatoes, sprinkled with salt and pepper, and our Signature Bravo sauce drizzle on our Tomato Basil Miche.
Oven roasted turkey breast, aged white cheddar, crisp mixed greens, vine-ripened tomatoes, red onions, garlic aioli, salt and pepper on our Country Rustic Sourdough.
A rich chunky chili with beef, kidney beans, fire roasted tomatoes and green chili peppers, simmered in a broth flavored with a blend of chilis, and cilantro.
Tender pieces of white-meat chicken simmered in a rich, perfectly seasoned homestyle chicken bone broth with curly egg noodles, sliced carrots, celery and herbs.
Vine-ripened pear tomatoes pureed with fresh cream for a velvety smooth flavor accented by hints of red pepper and oregano and topped with black pepper and sea salt croutons.
Romaine and crisp mixed greens tossed in a sweet white balsamic vinaigrette, topped with grilled chicken, grape tomatoes, red onions, toasted pecan pieces, feta, and apple chips.
Romaine and crisp mixed greens tossed in Green Goddess dressing, topped with grilled chicken, grape tomatoes, and pickled red onions, fresh avocado, applewood smoked bacon and a hard-boiled egg.
Romaine tossed in ranch dressing, with grilled chicken and drizzled with chipotle aioli, topped with fresh avocado, grape tomatoes, roasted corn, fresh cilantro, and blue corn tortilla strips.
Romaine and crisp mixed greens tossed in Greek Dressing, topped with our whole grain blend, grilled chicken, hummus, feta, red onions, zesty sweet Peppadew peppers, sliced cucumbers, and a sprinkle of shawarma seasoning.
Romaine and crisp mixed greens tossed in Greek Dressing, topped with our whole grain blend, hummus, feta, red onions, zesty sweet Peppadew peppers, sliced cucumbers, and a sprinkle of shawarma seasoning.
Romaine tossed in Greek dressing, topped with grilled chicken, grape tomatoes, feta, sliced cucumbers, red onions, kalamata olives, sliced pepperoncini peppers, salt and pepper.
Romaine tossed in Greek dressing, topped with grape tomatoes, feta, sliced cucumbers, red onions, kalamata olives, sliced pepperoncini peppers, salt and pepper.
Romaine and crisp mixed greens tossed in ranch dressing, topped with grape tomatoes, pickled red onions, applewood smoked bacon, feta, and a hard-boiled egg.
A salty, chocolaty, caramel confection big enough to share. A large cookie with semi-sweet chocolate, milk chocolate, caramel pieces, pretzels and then topped with flake salt.
Soft and smooth with hints of citrus, roasted nut and chocolate. A blend of Central and South American beans. Light bodied with a bright sweetness. Freshly ground in cafes.
Subtle nutty tones with wonderful coffee flavor. Serves 10. Brewed fresh, so please allow additional 15 min./tote to prepare your order. 120 fl oz per tote.
Rich, bold and full-bodied, balanced with a smoky accent and sweet chocolate notes. Harvested from Central and South America. Serves 10. 120 fl oz per tote.
Carefully roasted from Arabica beans and freshly brewed. Brewed fresh, so please allow additional 15 min./tote to prepare your order. Serves 10. 120 fl oz per tote.
Smoked, pulled chicken, scrambled egg, white cheddar, zesty sweet Peppadew peppers, fresh avocado and cilantro, salt and pepper, and chipotle aioli on Ciabatta.
A meal to feed the whole family, including 4 half sandwiches, 1 whole salad, 1 group soup, 1 whole French baguette and 4 Chocolate Chipper Cookies. Serves 4-6.
A meal to feed the whole family, including 4 half sandwiches, 1 whole salad, 1 group soup, 1 whole French baguette and 4 Chocolate Chipper Cookies. Serves 4-6.
Explore offerings from Panera Bread on 5335 E Southport Road in Indianapolis, with popular we’re here to help when and where you need us. available at this location.
We deliver your Panera favorites right to your door with contactless delivery. Just tell us where to leave your meal in the “Delivery Instructions” box when placing your order.
Panera pizza is here! Unbox the new flatbread pizzas in three varieties: margherita, chipotle chicken & bacon, and cheese. Pick it up, have it delivered, or grab it through the drive through for lunch or dinner.
$29!!!! For What?! What a ripoff! We are done with Panera. Too expensive and not at all worth the money.
LB
Liora Born
Aug 2, 2026
5.0
Great service and very friendly.
NN
Noah
Aug 2, 2026
3.0
Unusual lack of effort in cleaning the eating areas for a Panera, with stacks of 20 or so plates piled up across the restaurants tray returns and several tables left dirty. It should be effortless to place dishes for return.
Food and time to order were good as expected.
TT
Tina Thomas
Jul 21, 2026
1.0
Came in at 8:30 to get a late dinner. They close 90% of the dinning room I guess to clean so manager made us get up and move we had one of the only tables open right by the door. After closing the dinning room so you could not walk through it we decided to let our plates on the table considering the only available trash can was in the complete opposite corner of the resturant. Manager told us "actually costumers are responsible for clearing their table." I won't be back at this location. Coming in at 8:30 when the resturant does not close till 10 should be plenty time to sit in the dinning area and not be rushed out. We left at 9:15pm that does not seem so inconsiderate to deserve terrible service. Maybe they should change the hours if they want to go home so bad.
EP
Evan Perrault
Jul 20, 2026
5.0
Mrs shy is awesome she’s very kind welcoming and talkative. She is an amazing manager and leader for this store. Thank you shy to welcome us to the store to do preventive maintenance
What are the operating hours for Panera Bread on weekdays?
Panera Bread is open from 6:00 AM to 10:00 PM Monday through Saturday, and from 7:00 AM to 10:00 PM on Sundays.
Can I order delivery from Panera Bread?
Yes, Panera Bread offers delivery service every day during its operating hours.
What meal options are available at this Panera Bread location?
Panera Bread serves breakfast, lunch, brunch, and dinner with a focus on quality soups, salads, and sandwiches.
Does Panera Bread have a drive-thru and pick-up services?
Yes, this Panera Bread location offers drive-thru and pick-up services for your convenience.
What payment methods are accepted at Panera Bread?
Panera Bread accepts American Express, Cash, Discover, MasterCard, and Visa.
Can I order Panera Bread through their mobile app?
Yes, you can order using the Panera Bread app available on the Apple App Store for quick and easy ordering.
What nearby dining options are close to Panera Bread on E Southport Road?
Nearby dining options include Domino's Pizza, Thai Charm, Mr. Wok, Jimmy John's, Taco Bell, Rally's, Chick-fil-A, and Ben's Soft Pretzels, offering a variety of cuisines from pizza to Asian and fast food.
Are there nearby places to grab coffee or a snack near Panera Bread?
Yes, besides Panera Bread itself, Biggby Coffee and another Panera Bread café are nearby if you're looking for coffee or a quick bite.
What nearby services and stores could I visit around Panera Bread?
Nearby services include the United States Postal Service, multiple credit unions like Teachers Credit Union and Everwise Credit Union, as well as retail stores such as La-Z-Boy Furniture Galleries and Sherwin-Williams hardware store.
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