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Panera Bread Chicago welcomes guests to our café with warm hospitality and quality ingredients. We serve a variety of menu favorites for breakfast, lunch, and dinner—including fresh coffee, bakery items, salads, soups, and sandwiches—crafted to help you feel good about what you’re enjoying. Whether you’re dining in while enjoying complimentary Wi‑Fi, ordering online for Rapid Pick‑Up, enjoying delivery, or planning catering for a large group, Panera Bread Chicago is here to make your day a little better. Food as it should be.
Explore offerings from Panera Bread on 251 E Huron St in Chicago, with popular sandwiches, soups & mac, salads, and pastries & sweets available at this location.
Smoked, pulled chicken raised without antibiotics, smoked Gouda, fresh avocado and cilantro, zesty sweet Peppadew™ peppers and chipotle sauce on Black Pepper Focaccia.
Smoked, pulled chicken, fresh mozzarella, vine-ripened tomatoes, red onions, fresh basil, chipotle aioli, salt and pepper on our Black Pepper Focaccia.
Black Forest ham, soppressata, provolone, romaine, red onion, sliced pepperoncini peppers, garlic aioli, and Greek dressing on our toasted French Baguette.
Melty fresh mozzarella, vine-ripened tomatoes, chopped basil, crisp romaine & lettuce blend, sprinkled with salt and pepper, and balsamic vinaigrette and garlic aioli drizzle on our Ciabatta.
Oven-roasted turkey breast, applewood smoked bacon with aged white cheddar, crisp mixed greens, vine-ripened tomatoes, sprinkled with salt and pepper, and our Signature Bravo sauce drizzle on our Tomato Basil Miche.
Oven roasted turkey breast, aged white cheddar, crisp mixed greens, vine-ripened tomatoes, red onions, garlic aioli, salt and pepper on our Country Rustic Sourdough.
A rich chunky chili with beef, kidney beans, fire roasted tomatoes and green chili peppers, simmered in a broth flavored with a blend of chilis, and cilantro.
Tender pieces of white-meat chicken simmered in a rich, perfectly seasoned homestyle chicken bone broth with curly egg noodles, sliced carrots, celery and herbs.
Vine-ripened pear tomatoes pureed with fresh cream for a velvety smooth flavor accented by hints of red pepper and oregano and topped with black pepper and sea salt croutons.
Romaine and crisp mixed greens tossed in a sweet white balsamic vinaigrette, topped with grilled chicken, grape tomatoes, red onions, toasted pecan pieces, feta, and apple chips.
Romaine and crisp mixed greens tossed in Green Goddess dressing, topped with grilled chicken, grape tomatoes, and pickled red onions, fresh avocado, applewood smoked bacon and a hard-boiled egg.
Romaine tossed in ranch dressing, with grilled chicken and drizzled with chipotle aioli, topped with fresh avocado, grape tomatoes, roasted corn, fresh cilantro, and blue corn tortilla strips.
Romaine and crisp mixed greens tossed in Greek Dressing, topped with our whole grain blend, grilled chicken, hummus, feta, red onions, zesty sweet Peppadew peppers, sliced cucumbers, and a sprinkle of shawarma seasoning.
Romaine and crisp mixed greens tossed in Greek Dressing, topped with our whole grain blend, hummus, feta, red onions, zesty sweet Peppadew peppers, sliced cucumbers, and a sprinkle of shawarma seasoning.
Romaine tossed in Greek dressing, topped with grilled chicken, grape tomatoes, feta, sliced cucumbers, red onions, kalamata olives, sliced pepperoncini peppers, salt and pepper.
Romaine tossed in Greek dressing, topped with grape tomatoes, feta, sliced cucumbers, red onions, kalamata olives, sliced pepperoncini peppers, salt and pepper.
Romaine and crisp mixed greens tossed in ranch dressing, topped with grape tomatoes, pickled red onions, applewood smoked bacon, feta, and a hard-boiled egg.
A salty, chocolaty, caramel confection big enough to share. A large cookie with semi-sweet chocolate, milk chocolate, caramel pieces, pretzels and then topped with flake salt.
Soft and smooth with hints of citrus, roasted nut and chocolate. A blend of Central and South American beans. Light bodied with a bright sweetness. Freshly ground in cafes.
Subtle nutty tones with wonderful coffee flavor. Serves 10. Brewed fresh, so please allow additional 15 min./tote to prepare your order. 120 fl oz per tote.
Rich, bold and full-bodied, balanced with a smoky accent and sweet chocolate notes. Harvested from Central and South America. Serves 10. 120 fl oz per tote.
Carefully roasted from Arabica beans and freshly brewed. Brewed fresh, so please allow additional 15 min./tote to prepare your order. Serves 10. 120 fl oz per tote.
Smoked, pulled chicken, scrambled egg, white cheddar, zesty sweet Peppadew peppers, fresh avocado and cilantro, salt and pepper, and chipotle aioli on Ciabatta.
A meal to feed the whole family, including 4 half sandwiches, 1 whole salad, 1 group soup, 1 whole French baguette and 4 Chocolate Chipper Cookies. Serves 4-6.
A meal to feed the whole family, including 4 half sandwiches, 1 whole salad, 1 group soup, 1 whole French baguette and 4 Chocolate Chipper Cookies. Serves 4-6.
Explore offerings from Panera Bread on 251 E Huron St in Chicago, with popular we’re here to help when and where you need us. available at this location.
We deliver your Panera favorites right to your door with contactless delivery. Just tell us where to leave your meal in the “Delivery Instructions” box when placing your order.
Panera pizza is here! Unbox the new flatbread pizzas in three varieties: margherita, chipotle chicken & bacon, and cheese. Pick it up, have it delivered, or grab it through the drive through for lunch or dinner.
Every time I get Mac and cheese here it is like a gamble and the odds are against me. It’s like a 75% chance that it will be overcooked MUSH. I am a nurse and just want something good to eat on my lunch break. PLEASE do better!
ND
Nadine Delgado
Mar 30, 2026
5.0
Love this location!!! It's on the 2nd floor of NMH, so I can run down before my shift. They get busy, really fast!!
5days ago, my sandwich was missing a key ingredient, returned back after the 5 days w/receipt and Manager made sure I was credited as a happy return customer. Thank you Panera❤️
AB
A B
Mar 6, 2026
1.0
Rude morning staff. Cant be bothered to start working at schedule time to open registers. Happens so often.
TG
Thomas Gao
Mar 1, 2026
4.0
Thank you for the generous bag of sliced baguette as a special offer. (For night shift workers: first Thursday/Wednesday? night of each month is closed so avoid placing mobile orders around that time).
CR
C R
Feb 16, 2026
3.0
Review written 02/16/2026. This is the Panera on the 2nd floor of northwestern hospital in Downtown Chicago. This is a very busy location with tons of people lining up daily for orders.
The fountain drink area seems dirty and run down, I think it’s been the same fountains there for the past 5 years and does not seem clean.
So I recommend cleaning the fountain drink area.
Anytime I order a sip club drink here through the kiosk, they never prepare the cup. So I have to wait in the long line for a cup each time even if I order ahead. The online system says the cup is ready but there’s never a cup ready.
Also walking past this Panera there is kind of an overpowering scent, kind of nauseating in hospital setting
the workers seem to try really hard here and seem overworked and I hope they hire more employees to help out
Does Panera Bread at 251 E Huron St accept reservations?
No, Panera Bread does not accept reservations at this location.
What are the operating hours for Panera Bread Chicago?
Panera Bread Chicago at 251 E Huron St is open 24 hours every day of the week.
Can I order food online from Panera Bread Chicago?
Yes, you can order online for Rapid Pick-Up using their website or mobile app.
Does Panera Bread Chicago offer delivery service?
No, this location does not offer delivery service.
What type of meals does Panera Bread serve?
Panera Bread serves breakfast, lunch, brunch, and dinner meals.
Does Panera Bread Chicago have catering services?
Yes, this location offers catering services.
Is there seating available at Panera Bread Chicago?
Yes, seating is available and the attire is casual.
Are there any nearby hospitals to Panera Bread Chicago?
Yes, Prenst Hospital and Northwestern Memorial Hospital Feinberg Pavilion are nearby health facilities.
What nearby dining options are close to Panera Bread Chicago?
Nearby you can find Cafe L'Appetito, Greek Kitchen, and Subway for diverse dining experiences.
How can nearby places help visitors find Panera Bread at 251 E Huron St?
Nearby landmarks like Northwestern Memorial Hospital and the U.S. Bank can help orient visitors to Panera Bread's location on the 2nd floor at 251 E Huron St.
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