Fast Food RestaurantAmerican RestaurantHot Dog RestaurantRestaurantBurger Joint
Your nearby Five Guys at 4222 NW 16th Blvd in Gainesville is ready to offer you a classic take on burgers, hot dogs, fries, milkshakes and more! Whether it's using fresh ground beef (there are no freezers in our restaurants), double-cooking our fries in 100 percent peanut oil, hand-preparing fresh ingredients every morning or serving peanuts while you wait, we strive to provide the best experience each and every time you visit. With more than 250,000 ways to customize your burger and 1,000+ milkshake combinations, satisfying your craving is just a click away!
Explore offerings from Five Guys on 4222 NW 16th Blvd in Gainesville, with popular main menu available at this location.
US Menu
19 items
Main Menu
Hamburger
Fresh, hand-formed patties hot off the grill and placed on a soft, toasted sesame seed bun. Choose as many toppings as you want.
Cheeseburger
American-style cheese melted between fresh patties and placed on a soft, toasted sesame seed bun. Choose as many toppings as you want.
Bacon Burger
Hand-formed patties hot off the grill, layered with strips of crispy apple-wood smoked bacon and placed on a soft, toasted sesame seed bun. Choose as many toppings as you want.
Bacon Cheeseburger
Fresh patties hot off the grill with American- style cheese and crispy apple-wood smoked bacon. Placed on a soft, toasted sesame seed bun. Choose as many toppings as you want.
Little Hamburger
Fresh, hand-formed patty hot off the grill. Add as many toppings as you want.
Little Cheeseburger
Fresh, hand-formed patty hot off the grill with American- style cheese. Add as many toppings as you want.
Little Bacon Burger
Fresh, hand-formed patty hot off the grill with strips of crispy apple-wood smoked bacon on top. Add as many toppings as you want.
Little Bacon Cheeseburger
Fresh, hand-formed patty hot off the grill with American- style cheese and strips of crispy apple-wood smoked bacon on top. Add as many toppings as you want.
Kosher Style Hot Dog
All-beef hot dog, split and grilled lengthwise for a caramelized exterior with any of your favorite toppings.
Cheese Dog
All-beef hot dog, split and grilled lengthwise for a caramelized exterior with a layer of American- style cheese on top and any of your favorite toppings.
Bacon Dog
All-beef hot dog, split and grilled lengthwise for a caramelized exterior with a layer of apple-wood smoked bacon and any of your favorite toppings
Bacon Cheese Dog
All-beef hot dog, split and grilled lengthwise for a caramelized exterior, American-style cheese on top, a layer of apple-wood smoked bacon and any of your favorite toppings.
Veggie Sandwich
Freshly grilled onions, mushrooms and green peppers layered with lettuce and tomatoes on a soft, toasted sesame seed bun. Or start with the bun and build your own from scratch. Not a veggie burger.
Cheese Veggie Sandwich
Freshly grilled onions, mushrooms and green peppers layered with lettuce, tomatoes and slices of American style cheese on a soft, toasted sesame seed bun. Or start with the bun and cheese and build your own from scratch. Not a veggie burger.
Grilled Cheese
Slices of American style cheese melted on an inside-out sesame seed bun with toppings of your choice and grilled until golden brown.
BLT
Strips of crispy apple-wood smoked bacon from one of America’s last smokehouses, fresh tomato slices, mayo and hand-shredded lettuce on a soft, toasted sesame seed bun.
Five Guys Style
Freshly made boardwalk-style fries, cooked in pure, cholesterol-free, 100% peanut oil. Cut fresh and cooked twice – firm on the outside and mashed potato on the inside.
Cajun Style
Freshly made boardwalk-style fries, cooked in pure, cholesterol-free, 100% peanut oil, and then showered with a heavy dose of Cajun spice. Cut fresh and cooked twice – firm on the outside and mashed potato on the inside.
Milk Shake
Handspun vanilla milkshakes with or without whipped cream. Choose as many of our free mix-ins as you like.
Products & Services
1 list · 8 items
Services
8 items
Dine-In
Enjoy hand-cut fries and fresh, never frozen burgers made to order in our restaurant.
Takeout / Carryout
Order your Five Guys favorites at the counter and take them to go – hot, fresh and ready when you are.
Curbside Pickup
Skip the wait! Select locations bring your order directly to your car (check availability at your local Five Guys).
Delivery
Get Five Guys delivered fast through DoorDash, Uber Eats, Grubhub and other partner services at most locations.
Online Ordering
Order directly from our website or Five Guys app for limited-time offers, the best prices and to save your favorites!
Catering
Make everyone happy with Five Guys catering – fresh burgers, hand-cut fries and all the fixings (availability varies by location).
Gift Cards
Give the gift of Five Guys! Physical or digital gift cards available.
Mobile App Ordering
Download the Five Guys app for easy ordering, exclusive offers and your favorites exactly how you like them.
Reviews
4.4
920 reviews
5 stars
587
4 stars
197
3 stars
71
2 stars
36
1 star
29
SS
Sudo su
Jun 19, 2026
2.0
Ridiculously expensive, burger was just ok but pricing is completely out of touch. Won't be going back.
KA
Karim Alissa
May 2, 2026
5.0
Yasmine and the staff were amazing .
JI
jehad Al issa
May 2, 2026
5.0
Yasmin and al staff amazing friendly
Great place
DP
Dawn Pelham
May 2, 2026
4.0
It's been a long time since I've had a good buger from here. I like the fresh hamburger meat and it was still very juicy. I did notice a slight gamey taste which is new. But overall a good buger and the fresh French Fries hit the spot.
LG
Lee Golden
Apr 19, 2026
4.0
The food was very good but the prices in some cases were way out of line. A medium drink was nearly $6. The cheeseburger was nearly $9 and the fries were $6. My total bill for lunch was $23. Even though the food was good, I will not be going back to five guys.
What is the Five Guys story/How did you guys get your name?
Five Guys began its pursuit to redefine the global burger landscape in 1986 when Jerry and Janie Murrell asked three of their sons whether they wanted to start a business or go to college. Now, three decades after our first location opened in Arlington, Va., Five Guys – a fast-casual restaurant chain named for the Murrells' five sons – serves a classic take on hamburgers, fries and milkshakes in more than 1,700 locations across 24 countries.
You can read more about the story of Five Guys at www.FiveGuys.com!
How many restaurants does Five Guys have?
As of January 2026, we have more than 1,900 locations in over 24 countries!
Does Five Guys offer delivery?
Most North American locations offer delivery. The best way to find out if the location nearest to you offers delivery is to visit our website or download the app.
Additionally, we work with all major third-party delivery companies in the U.S., including DoorDash and Uber, so feel free to search for Five Guys through their platforms!
Does Five Guys offer gluten-free options?
The only products we offer that contain gluten are our buns, hot dogs (Canada only), HP sauce (UK only), and the malt vinegar condiment for our fries. In Canada, our Poutine Gravy condiment also contains gluten. All of our sandwiches, including burgers, hot dogs and the veggie sandwich, are available without a bun via our wrap or bowls.
While our crew members do all they can to avoid it, there is always a risk of cross-contamination. Please review our nutritional, ingredient and allergen chart for the most accurate information.
Why does Five Guys have peanuts for free?
Serving peanuts for free began as a way for people to pass the time while they waited for us to cook up their meals (way back in the day, before smartphones). It was such a hit, and has become such a Five Guys tradition, that we keep our stores stocked with peanuts to this day.
What is the best way to reheat leftover fries?
Leftover fries are excellent reheated in the oven (or Air Fryer). According to Chad Murrell, one of the Five Guys, just pop them in a 350-degree oven for about 10-15 minutes.
Also, give those leftover fries a try as hash browns, home fries, or even as the filling in an omelet.
Why is Five Guys switching from a fry cup to a fry bag?
We are switching to fry bags to ensure your fries stay fresher and as part of our larger commitment to the environment. The bags allow air to circulate better, so fries stay fresh during delivery and takeout. Same portions, same great fries – just smarter packaging that’s also better for the environment.
Does Five Guys at 4222 NW 16th Blvd accept reservations?
No, Five Guys does not accept reservations at this location.
What are the operating hours for Five Guys in Gainesville?
Five Guys is open daily from 11:00 AM to 10:00 PM.
Does Five Guys offer delivery and what are the delivery hours?
Yes, delivery is available daily from 11:00 AM to 9:30 PM. You can order online at https://order.fiveguys.com/location/millhopper/menu.
Can I place an order for pickup at Five Guys Gainesville?
Yes, Five Guys offers in-store pickup service at this location.
What types of payment does Five Guys in Gainesville accept?
They accept American Express, Android Pay, Apple Pay, Cash, Discover, Mastercard, and Visa.
What menu specialties does Five Guys offer at this location?
The specialties include hamburgers, cheeseburgers, fries, milkshakes, boardwalk fries, shakes, hot dogs, lettuce wrap, veggie sandwich, and grilled cheese.
Is the Five Guys restaurant at 4222 NW 16th Blvd family-friendly and accessible?
Yes, the restaurant welcomes children, has high chairs, a wheelchair accessible entrance and restroom.
What nearby food options can I explore before or after visiting Five Guys?
Nearby you can find Papa Johns Pizza for pizza lovers and The Flying Biscuit Cafe or Flying Biscuit Café, both offering American and southern style food and café options.
Where can I find health and wellness services close to Five Guys in Gainesville?
Nearby options include APEX Gainesville and APEX | High-Intensity Pilates for fitness, as well as several dental offices like Lozano Dental Care and Gainesville Dentistry Co.
Are there other shopping and specialty stores near Five Guys at 4222 NW 16th Blvd?
Yes, nearby are shopping options like etc boutique for women's clothing, Thornebrook Gallery for art and framing, and Crevasse's Florist of Gainesville for flowers and gifts.
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